Alpha-Emitting Radionuclides: Current Status and Future Perspectives

Research output: Contribution to journalReview articleContributedpeer-review



The use of radionuclides for targeted endoradiotherapy is a rapidly growing field in oncology. In particular, the focus on the biological effects of different radiation qualities is an important factor in understanding and implementing new therapies. Together with the combined approach of imaging and therapy, therapeutic nuclear medicine has recently made great progress. A particular area of research is the use of alpha-emitting radionuclides, which have unique physical properties associated with outstanding advantages, e.g., for single tumor cell targeting. Here, recent results and open questions regarding the production of alpha-emitting isotopes as well as their chemical combination with carrier molecules and clinical experience from compassionate use reports and clinical trials are discussed.


Original languageEnglish
Article number76
Pages (from-to)76
Number of pages20
Issue number1
Publication statusPublished - 8 Jan 2024

External IDs

ORCID /0009-0003-6004-8639/work/150883455
Scopus 85183389926
PubMed 38256909