Allergische Reaktionen auf COVID-19-Impfungen – Was HNO-Ärzte wissen sollten: Teil 1: Allgemeine Aspekte von Allergien auf Impfstoffe, immunologische Grundlagen von Allergien auf Impfstoffe, Immunmechanismen von allergischen und pseudoallergischen Reaktionen; Teil 2: Charakteristiken der mRNA-Impfstoffe BNT162b2 und mRNA-1273 zur Prophylaxe von COVID-19, weitere Impfstoff-Kandidaten und assoziierte Immunphänomene; Teil 3: Praktische Aspekte der Prophylaxe, Diagnostik und Therapie von Allergien auf COVID-19-Impfstoffe

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

Abstract

Vaccinations are the gold-standard in order to prevent dangerous infectious diseases. Within 12 months since the RNA sequence of SARS-COV2 has been published already two RNA vaccines against COVID-19 have been licensed and are broadly used in many relevant parts of the world. Matching the challenge of an unprecedented global pandemic unique collaborative approaches have made available several vaccines based on a variety of technological platforms that are under current development. This article explains the characteristics, biology and pharmacology of subunit-vaccines, inactivated and attenuated vaccines, Virus-like-Particle vaccines, recombinant strategies based on adenoviral vectors and newly developed and first time in human licensed RNA-vaccines that came into scope recently. Allergic reactions against the vaccine and its components have been reported but are yet uncommon, however need good documentation such as other side-effects and immune-phenomena. In rare cases where allergy against vaccine components such as PEGs is considered, such PEGs can be tested using a skin-prick test. Development of innovative vaccine technology and antiviral medication is of strategic relevance in the best sense of pandemic preparedness for the future.

Translated title of the contribution
Allergic reactions to COVID-19 vaccinations - What ENT doctors should know

Details

Original languageGerman
Pages (from-to)252-258
Number of pages7
JournalLaryngo- Rhino- Otologie
Volume100
Issue number4
Publication statusPublished - 1 Apr 2021
Peer-reviewedYes

External IDs

PubMed 33524996

Keywords

Sustainable Development Goals

ASJC Scopus subject areas

Keywords

  • allergy, anaphylaxis, BNT162b2, Covid-19, mRNA1273, vaccination