A common goal being pursued both in healthcare as well as in urban and transport planning is the integration of active mobility into everyday life. The main focus of active mobility in this project is on the transportation modes of walking and cycling. Research has shown that influencing factors of the spatial and transport systems, such as subjective socio-psychological as well as objective socio-demographic and socio-economic factors, have an effect on mobility behavior and thus on possible active mobility. The aim of the Federal Environment Agency's research project "Active Mobility: Better Quality of Life in Metropolitan Areas" was to identify motivational factors and obstacles with regard to active mobility in Germany, specifically in cities with at least 100,000 inhabitants. In order to be able to make representative statements about active mobility, a large-scale online survey was conducted in 2017 in twelve major German cities of different sizes and topographies. As a result, comprehensive evaluations of selected city groups, differentiated by city size and topography, were able to be presented as well as the ExWoSt model cities Aachen, Kiel, Cologne, and Leipzig. These were classified and further developed using figures from the household survey "Mobility in Cities - SrV". These two evaluations form the first focus of the results. Cross-city evaluations of motivation and obstacle factors for pedestrians and cyclists based on the online survey findings and the subsequent qualitative interviews form the second focus of the results. The third result module identifies the most important factors influencing walking and cycling, based on and using multivariate statistical methods. With regard to these factors, possible courses of action for the federal, state, and local authorities are developed.