Akathisia and Suicidal Ideation in First-Episode Schizophrenia
Research output: Contribution to journal › Letter › Contributed › peer-review
Contributors
Abstract
Patients with first-episode schizophrenia (FES) are known to be notably sensitive for developing extrapyramidal adverse effects, but the relation of akathisia and suicidal ideation has rarely been studied.
The current report is an ongoing analysis of an 8-week double-blind randomized controlled multicenter trial in 289 FES, comparing risperidone and haloperidol. Assessments were conducted weekly and included the Hillside Akathisia Scale and 21-item Hamilton Depression Rating Scale ratings.
Suicidal ideation was significantly associated with clinician observed akathisia, depressed mood, younger age, and use of propranolol. The allocated treatment, anxiety, and nervousness had no influence.
The present findings suggest a promoting effect of akathisia on suicidal ideation can not be ruled out in patients with FES.
The current report is an ongoing analysis of an 8-week double-blind randomized controlled multicenter trial in 289 FES, comparing risperidone and haloperidol. Assessments were conducted weekly and included the Hillside Akathisia Scale and 21-item Hamilton Depression Rating Scale ratings.
Suicidal ideation was significantly associated with clinician observed akathisia, depressed mood, younger age, and use of propranolol. The allocated treatment, anxiety, and nervousness had no influence.
The present findings suggest a promoting effect of akathisia on suicidal ideation can not be ruled out in patients with FES.
Details
| Original language | English |
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| Pages (from-to) | 694-698 |
| Journal | Journal of clinical psychopharmacology |
| Volume | 32 |
| Issue number | 5 |
| Publication status | Published - Oct 2012 |
| Peer-reviewed | Yes |
External IDs
| Scopus | 84865862570 |
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