Aggregation-resistant alpha-synuclein tetramers are reduced in the blood of Parkinson's patients

Research output: Contribution to journal › Research article › Contributed › peer-review

Contributors

  • Laura de Boni - , University of Bonn Medical Center (Author)
  • Amber Wallis - , UK Dementia Research Institute (DRI) (Author)
  • Aurelia Hays Watson - , UK Dementia Research Institute (DRI) (Author)
  • Alejandro Ruiz-Riquelme - , University of Santiago de Compostela (Author)
  • Louise-Ann Leyland - , UK Dementia Research Institute (DRI) (Author)
  • Thomas Bourinaris - , University College London (Author)
  • Naomi Hannaway - , UK Dementia Research Institute (DRI) (Author)
  • Ullrich Wüllner - , University of Bonn Medical Center (Author)
  • Oliver Peters - , German Center for Neurodegenerative Diseases (DZNE) - - Partner Site Berlin (Author)
  • Josef Priller - , Technical University of Munich (Author)
  • Björn H Falkenburger - , Department of Neurology, German Center for Neurodegenerative Diseases, Dresden site (Partner: DZNE of the Helmholtz Association) (Author)
  • Jens Wiltfang - , University of Aveiro (Author)
  • Mathias Bähr - , University Medical Center Göttingen (Author)
  • Inga Zerr - , University Medical Center Göttingen (Author)
  • Katharina Bürger - , Hospital of the Ludwig-Maximilians-University (LMU) Munich (Author)
  • Robert Perneczky - , Imperial College London (Author)
  • Stefan Teipel - , Rostock University Medical Centre (Author)
  • Matthias Löhle - , Rostock University Medical Centre (Author)
  • Wiebke Hermann - , Rostock University Medical Centre (Author)
  • Björn-Hendrik Schott - , University Medical Center Göttingen (Author)
  • Kathrin Brockmann - , University of Tübingen (Author)
  • Annika Spottke - , German Center for Neurodegenerative Diseases (DZNE) - Partner Site Bonn (Author)
  • Katrin Haustein - , University of Bonn Medical Center (Author)
  • Peter Breuer - , University of Bonn Medical Center (Author)
  • Henry Houlden - , University College London (Author)
  • Rimona S Weil - , UK Dementia Research Institute (DRI) (Author)
  • Tim Bartels - , UK Dementia Research Institute (DRI) (Author)

Abstract

The α-synuclein protein exists in different structural forms primarily as monomers, dimers, and tetramers in different human tissues. In the brain and blood, α-synuclein tetramer to monomer ratios are observed to be altered in sporadic and familial Parkinson’s disease (sPD), and dementia with Lewy bodies (DLB). (Figure presented.)

Details

Original languageEnglish
Pages (from-to)1657-1674
Number of pages18
JournalEMBO molecular medicine
Volume16
Issue number7
Publication statusPublished - Jul 2024
Peer-reviewedYes

External IDs

PubMedCentral PMC11250827
Scopus 85195313330
ORCID /0000-0002-2387-526X/work/176343351

Keywords

Sustainable Development Goals

Keywords

  • Aged, Female, Humans, Male, Middle Aged, Parkinson Disease/blood, Protein Aggregates, Protein Multimerization, alpha-Synuclein/metabolism