Affecting NF-κB cell signaling pathway in chronic lymphocytic leukemia by dendrimers-based nanoparticles

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • Ida Franiak-Pietryga - , Medical University of Łódź (Author)
  • Kinga Ostrowsk - , Lab Clin & Transplant Immunol & Genet (Author)
  • Henryk Maciejewski - , Wrocław University of Science and Technology (Author)
  • Barbara Ziemba - , Medical University of Łódź (Author)
  • Dietmar Appelhans - , Leibniz Institute of Polymer Research Dresden (Author)
  • Brigitte Voit - , Chair of Organic Chemistry of Polymers, Leibniz Institute of Polymer Research Dresden (Author)
  • Magdalena Jander - (Author)
  • Jacek Trelinski - , Medical University of Łódź (Author)
  • Maria Bryszewska - , Lodz University of Technology (Author)
  • Maciej Borowiec - , Medical University of Łódź (Author)

Abstract

The complex genetic diversity of chronic lymphocytic leukemia (CLL) makes it difficult to determine the effective and durable therapy beneficial to patients. During the several past years' significant insights in the biology of the disease and its treatment have been made, allowing for the identification of promising novel therapeutic agents. The investigation of signaling pathways to understand the biological character of CLL together with the development of molecular profiling is key in personalized approach in therapy for this disease. As it was already proven, maltotriose (M3) modified fourth generation poly(propylene imine) dendrimers (PPI-G4) modulate BCR, TRAIL and WNT signaling pathway gene expression in CLL cells and strongly influence their survival by inducing apoptosis and inhibiting proliferation. The aim of this study was to evaluate the influence of PPI-G4-M3 dendrimers on NF kappa B pathway gene expression in CLL (MEC-1) cells with 60 K microarray, as it is one of the major factors in the pathogenesis of B-cell neoplasms. The findings were compared with those obtained with Fludarabine (FA) and the results indicate that PPI-G4-M3 dendrimers affect the expression of the examined genes and exert comparable effect on the CLL cells to FA. Dendrimers are one of the most potent groups of nanometer-sized macromolecules for closing the gap between the present ineffective treatment and the future effective personalized therapy due to their potential versatile biological properties.

Details

Original languageGerman
Pages (from-to)33-38
Number of pages6
JournalToxicology and applied pharmacology : TAP
Volume357
Publication statusPublished - 15 Oct 2018
Peer-reviewedYes

External IDs

PubMed 30125597
Scopus 85052741137
ORCID /0000-0002-4531-691X/work/148608061

Keywords

Keywords

  • Chronic lymphocytic leukemia (CLL), Gene expression, Glycodendrimer, NF-kappa B, PPI dendrimer, Signaling pathway