Adrenal medulla development and medullary-cortical interactions
Research output: Contribution to journal › Review article › Contributed › peer-review
Contributors
Abstract
The mammalian adrenal gland is composed of two distinct tissue types in a bidirectional connection, the catecholamine-producing medulla derived from the neural crest and the mesoderm-derived cortex producing steroids. The medulla mainly consists of chromaffin cells derived from multipotent nerve-associated descendants of Schwann cell precursors. Already during adrenal organogenesis, close interactions between cortex and medulla are necessary for proper differentiation and morphogenesis of the gland. Moreover, communication between the cortex and the medulla ensures a regular function of the adult adrenal. In tumor development, interfaces between the two parts are also common. Here, we summarize the development of the mammalian adrenal medulla and the current understanding of the cortical-medullary interactions under development and in health and disease.
Details
Original language | English |
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Article number | 111258 |
Pages (from-to) | 111258 |
Journal | Molecular and cellular endocrinology |
Volume | 528 |
Publication status | Published - 15 May 2021 |
Peer-reviewed | Yes |
External IDs
Scopus | 85103701514 |
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ORCID | /0000-0002-6932-333X/work/148144970 |
Keywords
Keywords
- Adrenal Cortex/growth & development, Adrenal Medulla/growth & development, Animals, Catecholamines/metabolism, Cell Differentiation, Chromaffin Cells/metabolism, Humans, Neural Crest/metabolism