Adenoma and colorectal cancer risks in Lynch syndrome, Lynch-like syndrome and familial colorectal cancer type X

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • Leipzig University
  • Heidelberg University 
  • German Cancer Research Center (DKFZ)
  • University of Bonn
  • University of Cologne
  • Ludwig Maximilian University of Munich
  • MGZ - Medical Genetics Center Munich
  • Ruhr University Bochum
  • Center for Hereditary Tumors
  • Heinrich Heine University Düsseldorf

Abstract

Lynch syndrome (LS), Lynch-like syndrome (LLS) and familial colorectal cancer type X (FCCX) are different entities of familial cancer predisposition leading to an increased risk of colorectal cancer (CRC). The aim of this prospective study was to characterise and to compare the risks for adenoma and CRC in these three risk groups. Data was taken from the registry of the German Consortium for Familial Intestinal Cancer. Patients were prospectively followed up in an intensified colonoscopic surveillance programme that included annual examinations. Cumulative risks for adenoma and CRC were calculated separately for LS, LLS and FCCX, and then for males and females. Multivariate Cox regression was used to analyse the independent contributions of risk group, mismatch repair gene (within LS), sex and previous adenoma. The study population comprised 1448 individuals (103 FCCX, 481 LLS and 864 LS). The risks were similar for colorectal adenomas, but different for first and metachronous CRC between the three risk groups. CRC risk was highest in LS, followed by LLS and lowest in FCCX. Male sex and a prevalent adenoma in the index colonoscopy were associated with a higher risk for incident adenoma and CRC. In patients with LS, CRC risks were particularly higher in female MSH2 than MLH1 carriers. Our study may support the development of risk-adapted surveillance policies in LS, LLS and FCCX.

Details

Original languageEnglish
Pages (from-to)56-66
Number of pages11
JournalInternational journal of cancer
Volume150
Issue number1
Publication statusPublished - 1 Jan 2022
Peer-reviewedYes

External IDs

PubMed 34469588

Keywords

Sustainable Development Goals

ASJC Scopus subject areas

Keywords

  • cancer risk, familial colorectal cancer type X, Lynch syndrome, Lynch-like syndrome, prospective study

Library keywords