Addiction Research Consortium: Losing and regaining control over drug intake (ReCoDe)—From trajectories to mechanisms and interventions

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • Andreas Heinz - , Charité – Universitätsmedizin Berlin (Author)
  • Falk Kiefer - , Heidelberg University  (Author)
  • Michael N. Smolka - , Department of Psychiatry and Psychotherapy (Author)
  • Tanja Endrass - , Chair of Addiction Research (Author)
  • Christian Beste - , Department of Child and Adolescent Psychiatry and Psychotherapy (Author)
  • Anne Beck - , Charité – Universitätsmedizin Berlin (Author)
  • Shuyan Liu - , Charité – Universitätsmedizin Berlin (Author)
  • Alexander Genauck - , Charité – Universitätsmedizin Berlin (Author)
  • Lydia Romund - , Charité – Universitätsmedizin Berlin (Author)
  • Tobias Banaschewski - , University Hospital Heidelberg (Author)
  • Felix Bermpohl - , Free University of Berlin (Author)
  • Lorenz Deserno - , Technische Universitat Dresden Aktiengesellschaft (TUDAG ), SOAS University of London (Author)
  • Raymond J. Dolan - , SOAS University of London (Author)
  • Daniel Durstewitz - , Heidelberg University  (Author)
  • Ulrich Ebner-Priemer - , Helmholtz Association of German Research Centres (Author)
  • Herta Flor - , Central Institute of Mental Health (CIMH) (Author)
  • Anita C. Hansson - , Heidelberg University  (Author)
  • Christine Heim - , Free University of Berlin, Pennsylvania State University (Author)
  • Derik Hermann - , Central Institute of Mental Health (CIMH), Heidelberg University  (Author)
  • Stefan Kiebel - , Neuroimaging Center, Chair of cognitive computational neuroscience (Author)
  • Peter Kirsch - , Central Institute of Mental Health (CIMH) (Author)
  • Clemens Kirschbaum - , Chair of Biopsychology (Author)
  • Georgia Koppe - , Heidelberg University  (Author)
  • Michael Marxen - , Neuroimaging Center, Department of Psychiatry and Psychotherapy (Author)
  • Andreas Meyer-Lindenberg - , Heidelberg University  (Author)
  • Wolfgang E. Nagel - , Center for Information Services and High Performance Computing (ZIH) (Author)
  • Hamid R. Noori - , Heidelberg University , Max Planck Society (Author)
  • Maximilian Pilhatsch - , Department of Psychiatry and Psychotherapy (Author)
  • Josef Priller - , Free University of Berlin, Edinburgh Napier University (Author)
  • Marcella Rietschel - , Heidelberg University  (Author)
  • Nina Romanczuk-Seiferth - , Free University of Berlin (Author)
  • Florian Schlagenhauf - , Free University of Berlin (Author)
  • Wolfgang H. Sommer - , Central Institute of Mental Health (CIMH), Heidelberg University  (Author)
  • Jan Stallkamp - , Project Grp Automat Med & Biotechnol (Author)
  • Andreas Stroehle - , Free University of Berlin (Author)
  • Ann-Kathrin Stock - , Department of Child and Adolescent Psychiatry and Psychotherapy (Author)
  • Georg Winterer - , Free University of Berlin (Author)
  • Christine Winter - , Free University of Berlin (Author)
  • Henrik Walter - , Free University of Berlin (Author)
  • Stephanie Witt - , Heidelberg University  (Author)
  • Sabine Vollstaedt-Klein - , Central Institute of Mental Health (CIMH) (Author)
  • Michael A. Rapp - , University of Potsdam (Author)
  • Heike Tost - , Heidelberg University  (Author)
  • Rainer Spanagel - , Heidelberg University  (Author)

Abstract

One of the major risk factors for global death and disability is alcohol, tobacco, and illicit drug use. While there is increasing knowledge with respect to individual factors promoting the initiation and maintenance of substance use disorders (SUDs), disease trajectories involved in losing and regaining control over drug intake (ReCoDe) are still not well described. Our newly formed German Collaborative Research Centre (CRC) on ReCoDe has an interdisciplinary approach funded by the German Research Foundation (DFG) with a 12-year perspective. The main goals of our research consortium are (i) to identify triggers and modifying factors that longitudinally modulate the trajectories of losing and regaining control over drug consumption in real life, (ii) to study underlying behavioral, cognitive, and neurobiological mechanisms, and (iii) to implicate mechanism-based interventions. These goals will be achieved by: (i) using mobile health (m-health) tools to longitudinally monitor the effects of triggers (drug cues, stressors, and priming doses) and modify factors (eg, age, gender, physical activity, and cognitive control) on drug consumption patterns in real-life conditions and in animal models of addiction; (ii) the identification and computational modeling of key mechanisms mediating the effects of such triggers and modifying factors on goal-directed, habitual, and compulsive aspects of behavior from human studies and animal models; and (iii) developing and testing interventions that specifically target the underlying mechanisms for regaining control over drug intake.

Details

Original languageEnglish
Article numbere12866
Pages (from-to)879-894
Number of pages6
JournalAddiction Biology
Volume25
Issue number2
Early online dateDec 2019
Publication statusPublished - 14 May 2020
Peer-reviewedYes

External IDs

Scopus 85076764754
researchoutputwizard legacy.publication#88066
ORCID /0000-0002-8845-8803/work/141545256
ORCID /0000-0001-8870-0041/work/142251337
ORCID /0000-0002-2989-9561/work/146788732
Core 482231471
WOS 000503535700001
PubMed 31859437
ORCID /0000-0001-5398-5569/work/150329438

Keywords

Keywords

  • addiction, alternative rewards, animal and computational models, cognitive-behavioral control, craving and relapse, habit formation