A stable and replicable neural signature of lifespan adversity in the adult brain

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • Nathalie E Holz - , Radboud University Nijmegen (Author)
  • Mariam Zabihi - , Radboud University Nijmegen (Author)
  • Seyed Mostafa Kia - , Radboud University Nijmegen (Author)
  • Maximillian Monninger - , National Center for Tumor Diseases (NCT) Heidelberg (Author)
  • Pascal-M Aggensteiner - , National Center for Tumor Diseases (NCT) Heidelberg (Author)
  • Sebastian Siehl - , University Hospital Schleswig-Holstein Campus Kiel (Author)
  • Dorothea L Floris - , Radboud University Nijmegen (Author)
  • Arun L W Bokde - , Trinity College Dublin (Author)
  • Sylvane Desrivières - , King's College Hospital NHS Foundation Trust (Author)
  • Herta Flor - , National Center for Tumor Diseases (NCT) Heidelberg (Author)
  • Antoine Grigis - , French Alternative Energies and Atomic Energy Commission (CEA) (Author)
  • Hugh Garavan - , Northern Vermont University (Author)
  • Penny Gowland - , Park University, Missouri (Author)
  • Andreas Heinz - , Charité – Universitätsmedizin Berlin (Author)
  • Rüdiger Brühl - , Physikalisch-Technische Bundesanstalt (Author)
  • Jean-Luc Martinot - , INSERM - Institut national de la santé et de la recherche médicale (Author)
  • Marie-Laure Paillère Martinot - , Pitié-Salpêtrière Hospital (Author)
  • Dimitri Papadopoulos Orfanos - , French Alternative Energies and Atomic Energy Commission (CEA) (Author)
  • Tomáš Paus - , University of Montreal (Author)
  • Luise Poustka - , National Center for Tumor Diseases (NCT) Heidelberg (Author)
  • Juliane H Fröhner - , Department of Psychiatry and Psychotherapy (Author)
  • Michael N Smolka - , Department of Psychiatry and Psychotherapy (Author)
  • Nilakshi Vaidya - , Charité – Universitätsmedizin Berlin (Author)
  • Henrik Walter - , Mental Health Institute Berlin GmbH (Author)
  • Robert Whelan - , Trinity College Dublin (Author)
  • Gunter Schumann - , Charité – Universitätsmedizin Berlin (Author)
  • Andreas Meyer-Lindenberg - , National Center for Tumor Diseases (NCT) Heidelberg (Author)
  • Daniel Brandeis - , National Center for Tumor Diseases (NCT) Heidelberg (Author)
  • Jan K Buitelaar - , Radboud University Nijmegen (Author)
  • Frauke Nees - , University Hospital Schleswig-Holstein Campus Kiel (Author)
  • Christian Beckmann - , Radboud University Nijmegen (Author)
  • Tobias Banaschewski - , National Center for Tumor Diseases (NCT) Heidelberg (Author)
  • Andre F Marquand - , Radboud University Nijmegen (Author)

Abstract

Environmental adversities constitute potent risk factors for psychiatric disorders. Evidence suggests the brain adapts to adversity, possibly in an adversity-type and region-specific manner. However, the long-term effects of adversity on brain structure and the association of individual neurobiological heterogeneity with behavior have yet to be elucidated. Here we estimated normative models of structural brain development based on a lifespan adversity profile in a longitudinal at-risk cohort aged 25 years (n = 169). This revealed widespread morphometric changes in the brain, with partially adversity-specific features. This pattern was replicated at the age of 33 years (n = 114) and in an independent sample at 22 years (n = 115). At the individual level, greater volume contractions relative to the model were predictive of future anxiety. We show a stable neurobiological signature of adversity that persists into adulthood and emphasize the importance of considering individual-level rather than group-level predictions to explain emerging psychopathology.

Details

Original languageEnglish
Pages (from-to)1603-1612
Number of pages10
JournalNature neuroscience
Volume26
Issue number9
Publication statusPublished - Sept 2023
Peer-reviewedYes

External IDs

PubMedCentral PMC10471497
Scopus 85168538029
ORCID /0000-0001-5398-5569/work/150329565
ORCID /0000-0002-8493-6396/work/150330264

Keywords

Keywords

  • Adult, Humans, Longevity, Brain, Anxiety, Mental Disorders, Neurobiology