A postresection perfusion deficit in the right colon is an independent predictor of perioperative outcome after major hepatectomy

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

Abstract

Background: There is a strong interaction between hepatic hemodynamics and perfusion in the splanchnic system. However, little is known about differences in perfusion in different splanchnic compartments and their changes after hepatectomy. Methods: Perfusion in various splanchnic compartments (ie, stomach, small intestine, right and left colon, liver) was assessed pre- and post-hepatectomy by intraoperative laser Doppler flowmetry. Differences of splanchnic perfusion between compartments were evaluated by ANOVA, and risk factors of postoperative complications (graded by the comprehensive complication index [CCI]) were analyzed by univariate and multivariate analyses. A prediction model of postoperative complications was developed. Results: A total of 50 and 29 patients with major and minor hepatectomy were enrolled. Splanchnic perfusion at baseline varied significantly across different splanchnic compartments with highest values in the small bowel and right colon (P <.001). Major hepatectomy induced a significant perfusion decrease in the stomach (P =.006), right colon (P <.001) and small bowel (P =.035). A postresection perfusion deficit in the right colon with values below 254 perfusion units (PU) was identified as an independent predictor of clinically relevant complications after major hepatectomy (concordance index: 0.79, 95% CI 0.66-0.87, P =.002). Bootstrap validation confirmed internal validity and excellent calibration. Conclusions: Major hepatectomy causes significant reduction of splanchnic perfusion. An intraoperative posthepatectomy microcirculatory perfusion deficit of the right colon is a strong and independent predictor of clinically relevant postoperative complications after major hepatectomy.

Details

Original languageEnglish
Pages (from-to)785-797
Number of pages13
Journal Journal of hepato-biliary pancreatic sciences : official journal of the Japanese Society of Hepato-Biliary-Pancreatic Surgery and the Asian-Pacific Hepato-Pancreato-Biliary Association
Volume29
Issue number7
Publication statusPublished - Jul 2022
Peer-reviewedYes

External IDs

PubMed 34856068

Keywords

ASJC Scopus subject areas

Keywords

  • circulation, complication, flowmetry, hepatic buffer

Library keywords