A novel target (Oxidation Resistant 2) in Arabidopsis thaliana to reduce clubroot disease symptoms via the salicylic acid pathway without growth penalties

Research output: Contribution to journalResearch articleContributedpeer-review



The clubroot disease (Plasmodiophora brassicae) is one of the most damaging diseases worldwide among brassica crops. Its control often relies on resistant cultivars, since the manipulation of the disease hormones, such as salicylic acid (SA) alters plant growth negatively. Alternatively, the SA pathway can be increased by the addition of beneficial microorganisms for biocontrol. However, this potential has not been exhaustively used. In this study, a recently characterized protein Oxidation Resistant 2 (OXR2) from Arabidopsis thaliana is shown to increase the constitutive pathway of SA defense without decreasing plant growth. Plants overexpressing AtOXR2 (OXR2-OE) show strongly reduced clubroot symptoms with improved plant growth performance, in comparison to wild type plants during the course of infection. Consequently, oxr2 mutants are more susceptible to clubroot disease. P. brassicae itself was reduced in these galls as determined by quantitative real-time PCR. Furthermore, we provide evidence for the transcriptional downregulation of the gene encoding a SA-methyltransferase from the pathogen in OXR2-OE plants that could contribute to the phenotype.


Original languageEnglish
Pages (from-to)9
JournalHorticulturae : open access journal
Issue number1
Publication statusPublished - Jan 2022

External IDs

Scopus 85123699167


DFG Classification of Subject Areas according to Review Boards

ASJC Scopus subject areas


  • Arabidopsis thaliana, Clubroot disease, Defense induction, Oxidation resistant 2, PBSMT, Plasmodiophora brassicae, Salicylic acid

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