A non-fatal oleander poisoning
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
The study presents a case of non-fatal poisoning with oleander blooms in a 47-year-old female, with emphasis on the importance of toxicological service in a clinical emergency. After repeated vomiting at home, the patient was admitted at the hospital with cardiac symptoms more than 18 h after the ingestion. Serum samples were assayed immunochemically for digitoxin-related compounds by electrochemiluminescent immunoassay, and using HPLC/MS/MS analysis for oleandrin, the main cardiac glycoside of Nerium oleander. Confirming the non-specific immunoassay results, which are often clinically over-interpreted, oleandrin was detected by HPLC/MS/MS in the serum sample in a concentration of 1.6 ng/ml upon admission. Comparison with previous reports indicates that single compound analysis only permits a toxicological assessment for oleander poisoning and results in the proposal to classify an oleandrin level between 1.0 and 2.0 ng/ml as toxic blood plasma/serum concentration.
Details
Original language | English |
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Pages (from-to) | 236-240 |
Number of pages | 5 |
Journal | International journal of legal medicine |
Volume | 119 |
Issue number | 4 |
Publication status | Published - Jun 2005 |
Peer-reviewed | Yes |
External IDs
Scopus | 21744441471 |
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WOS | 000230843600010 |
PubMed | 15906057 |
ORCID | /0000-0001-7049-186X/work/142239872 |
ORCID | /0000-0003-1526-997X/work/142247206 |
Keywords
ASJC Scopus subject areas
Keywords
- HPLC/MS/MS, Immunoassay, Nerium oleander, Oleandrin, Poisoning