A latent cardiomyocyte regeneration potential in human heart disease

Research output: Preprint/documentation/reportPreprint



Cardiomyocytes in the adult human heart show a regenerative capacity, with an annual renewal rate around 0.5%. Whether this regenerative capacity of human cardiomyocytes is employed in heart failure has been controversial. Using retrospective 14C birth dating we analyzed cardiomyocyte renewal in patients with end-stage heart failure. We show that cardiomyocyte generation is minimal in end-stage heart failure patients at rates 18-50 times lower compared to the healthy heart. However, patients receiving left ventricle support device therapy, who showed significant functional and structural cardiac improvement, had a >6-fold increase in cardiomyocyte renewal relative to the healthy heart. Our findings reveal a substantial cardiomyocyte regeneration potential in human heart disease, which could be exploited therapeutically.


Original languageEnglish
Number of pages32
Publication statusPublished - 17 Sept 2023
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External IDs

PubMedCentral PMC10515906
ORCID /0000-0001-6466-2589/work/147673183
ORCID /0000-0003-0137-5106/work/147674384
ORCID /0000-0003-1065-4107/work/147674463