Conceptualizing, developing, and using digital platforms to support industrial symbiosis has gained momentum to facilitate sustainable industrial development. However, current research provides little insight and scarce guidance for the design of platform-supported industrial symbiosis. Furthermore, experiences and viewpoints of (potential) platform users and providers are hardly captured. Moreover, the actors’ roles and the suitability of platforms for different industrial symbiosis settings remain neglected. These aspects are relevant for providing, maintaining, continuously developing, accepting, and using the platforms themselves. Therefore, within a long-term research project, we developed the Digital Industrial Symbiosis Ecosystem (DISE) concept as an artifact to guide developing and disseminating industrial symbiosis platforms (ISP). This research is embedded in a design science research approach focusing on design criteria for ISPs. In this paper, we present how we developed and evaluated the DISE concept from the perspective of design science.