A comparison between nailfold capillaroscopy patterns in adulthood in juvenile and adult-onset systemic sclerosis: A EUSTAR exploratory study

Research output: Contribution to journalResearch articleContributedpeer-review


  • University of Milan
  • Orthopedic Institute Gaetano Pini, Milan
  • Medical Statistics and Biometry
  • Ghent University
  • University of Genoa
  • Center for Pediatric and Adolescent Rheumatology Hamburg
  • University of Valencia
  • Université Paris Cité
  • Russian Academy of Medical Sciences
  • Grigore T. Popa University of Medicine and Pharmacy
  • Federal University of São Paulo
  • Charles University Prague
  • Strada Ion Movila
  • Vilnius University
  • University of Foggia
  • IRCCS Fondazione Policlinico San Matteo - Pavia
  • Unità di Reumatologia AOUI Verona
  • Complutense University
  • Universidad de Buenos Aires
  • Federico II University Hospital
  • University of Pecs
  • University of Coimbra
  • Hospital Universitario Madrid Norte Sanchinarro
  • Universidade Federal do Paraná
  • University of Copenhagen
  • A.O.U. Policlinico Vittorio Emanuele
  • University of Zurich
  • Université de Lille
  • Clinical Emergency Hospital St. Pantelimon
  • Technical University of Munich
  • Justus Liebig University Giessen
  • Marche Polytechnic University
  • University of Oslo
  • Hospital Regional Universitario Jose Ma Cabral y Baez
  • Carol Davila University of Medicine and Pharmacy
  • University of Florence
  • Brescia Civil Hospital


Objective: Qualitative capillaroscopy patterns in juvenile- and adult-onset systemic sclerosis (SSc) were studied in adulthood using data from the EULAR Scleroderma Trials and Research (EUSTAR) database. Methods: Data collected between June 2004 and April 2013 were examined with focus on capillaroscopy. In this retrospective exploratory study, series of patients with juvenile-onset SSc were matched with series of adult-onset SSc having the same gender and autoantibody profile. Results: 30 of 123 patients with juvenile-onset and 2108 of 7133 with adult-onset SSc had data on capillaroscopy. Juvenile-onset SSc showed scleroderma pattern more frequently than adult-onset SSc (93.3% and 88%). The OR was 2.44 and 95% CI 0.57-10.41. An active scleroderma pattern was present in 58% of juvenile- and 61% of adult-onset SSc. The OR was 0.91 and 95% CI 0.28-2.93. The late scleroderma pattern was present in 61% of juvenile- and 55.5% of adult-onset SSc. The OR was 1.06 and 95% CI 0.34-3.56. Conclusion: This is the first exploratory study on the comparison of capillaroscopy between juvenile- and adult-onset SSc in adulthood. Juvenile-onset SSc had an increase prevalence of scleroderma pattern, but a similar distribution of the three patterns was suggested. Further studies are needed to define this issue.


Original languageEnglish
Pages (from-to)19-24
Number of pages6
JournalMicrovascular Research
Issue number102
Publication statusE-pub ahead of print - 4 Aug 2015

External IDs

PubMed 26254260
ORCID /0000-0002-4330-1861/work/151982028



  • Capillaroscopy, EUSTAR, Juvenile systemic sclerosis, Microcirculation, Nailfold capillaroscopy, Systemic sclerosis, Videocapillaroscopy

Library keywords