A case of recurrent herpes simplex 2 encephalitis, VZV reactivations, and dominant partial interferon-gamma-receptor-1 deficiency supports relevance of IFNgamma for antiviral defense in humans

Research output: Contribution to journal › Research article › Contributed › peer-review

Contributors

  • Julia Körholz - , Department of Child and Adolescent Psychiatry and Psychotherapy (Author)
  • Jochen Schäfer - , Department of Neurology, University Hospital Carl Gustav Carus Dresden (Author)
  • Catharina Schuetz - , Department of Paediatrics, Department of Child and Adolescent Psychiatry and Psychotherapy (Author)
  • Joachim Roesler - , Department of Child and Adolescent Psychiatry and Psychotherapy (Author)

Abstract

BACKGROUND: Unlike infections with mycobacteria, reports of unusual viral infections in interferon-gamma-receptor (IFNγR) deficient patients are scarce. Therefore, discussion about increased susceptibility to viral infections in these patients is ongoing.

CASE PRESENTATION: We describe a 51-year-old male with dominant partial interferon-gamma-receptor-1 (IFNγR1)-deficiency and recurrent Herpes simplex 2 meningoencephalitis as well as other viral reactivations since childhood.

CONCLUSIONS: This case further confirms an enhanced risk for viral disease in IFNγR-deficient patients and a role of interferon gamma for human antiviral defense.

Details

Original languageEnglish
Pages (from-to)14
JournalMolecular and Cellular Pediatrics
Volume7
Issue number1
Publication statusPublished - 14 Oct 2020
Peer-reviewedYes

External IDs

PubMedCentral PMC7554277
ORCID /0009-0003-6519-0482/work/162845243
ORCID /0000-0001-6313-4434/work/162846118

Keywords

Sustainable Development Goals