This paper presents a new branch-and-cut algorithm based on infeasible path elimination for the three-dimensional loading capacitated vehicle routing problem (3L-CVRP) with different loading problem variants. We show that a previously infeasible route can become feasible by adding a new customer if support constraints are enabled in the loading subproblem and call this the incremental feasibility property. Consequently, different infeasible path definitions apply to different 3L-CVRP variants and we introduce several variant-depending lifting steps to strengthen infeasible path inequalities. The loading subproblem is solved exactly using a flexible constraint programming model to determine the feasibility or infeasibility of a route. An extreme point-based packing heuristic is implemented to reduce time-consuming calls to the exact loading algorithm. Furthermore, we integrate a start solution procedure and periodically combine memoized feasible routes in a set-partitioning-based heuristic to generate new upper bounds. A comprehensive computational study, employing well-known benchmark instances, showcases the significant performance improvements achieved through the algorithmic enhancements. Consequently, we not only prove the optimality of many best-known heuristic solutions for the first time but also introduce new optimal and best solutions for a large number of instances.