4D Biofabrication: 3D Cell Patterning Using Shape-Changing Films

Research output: Contribution to journal › Research article › Contributed › peer-review

Contributors

  • Vladislav Stroganov - , University of Georgia (Author)
  • Jitendra Pant - , University of Georgia (Author)
  • Georgi Stoychev - , University of Georgia (Author)
  • Andreas Janke - , Leibniz Institute of Polymer Research Dresden (Author)
  • Dieter Jehnichen - , Leibniz Institute of Polymer Research Dresden (Author)
  • Andreas Fery - , Chair of Physical Chemistry of Polymeric Materials, Leibniz Institute of Polymer Research Dresden (Author)
  • Hitesh Handa - , University of Georgia (Author)
  • Leonid Ionov - , University of Georgia, University of Bayreuth (Author)

Abstract

A novel approach for fabrication of 3D cellular structures using new thermosensitive shape-changing polymer films with photolithographically patterned surface—4D biofabrication is reported. The surface of shape-changing polymer films is patterned to selectively adsorb cells in specific regions. The 2D cell pattern is converted to the 3D cell structure after temperature-induced folding of the polymer films. This approach has a great potential in the field of tissue engineering and bioscaffolds fabrication.

Details

Original languageEnglish
Article number1706248
JournalAdvanced functional materials
Volume28
Issue number11
Publication statusPublished - 14 Mar 2018
Peer-reviewedYes

Keywords

ASJC Scopus subject areas

Keywords

  • actuators, folding, hydrogels, thermoresponsive polymers

Library keywords