18F-FDG PET/CT-derived total lesion glycolysis predicts abscess formation in patients with surgically confirmed infective endocarditis: Results of a retrospective study at a tertiary center

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • Sabine Julia Maria Sag - , University of Regensburg (Author)
  • Karin Menhart - , University of Regensburg (Author)
  • Florian Hitzenbichler - , University of Regensburg (Author)
  • Christof Schmid - , University of Regensburg (Author)
  • Frank Hofheinz - , Helmholtz-Zentrum Dresden-Rossendorf (Author)
  • Jörg van den Hoff - , Department of Nuclear Medicine, Helmholtz-Zentrum Dresden-Rossendorf (Author)
  • Lars Siegfried Maier - , University of Regensburg (Author)
  • Dirk Hellwig - , University of Regensburg (Author)
  • Jirka Grosse - , University of Regensburg (Author)
  • Can Martin Sag - , University of Regensburg (Author)

Abstract

Background: Abnormal activity of 18F-FDG PET/CT is a major Duke criterion in the diagnostic work-up of infective prosthetic valve endocarditis (IE). We hypothesized that quantitative lesion assessment by 18F-FDG PET/CT-derived standard maximum uptake ratio (SURmax), metabolic volume (MV), and total lesion glycolysis (TLG) might be useful in distinct subgroups of IE patients (e.g. IE-related abscess formation). Methods: All patients (n = 27) hospitalized in our tertiary IE referral medical center from January 2014 to October 2018 with preoperatively performed 18F-FDG PET/CT and surgically confirmed IE were included into this retrospective analysis. Results: Patients with surgically confirmed abscess formation (n = 10) had significantly increased MV (by ~ fivefold) and TLG (by ~ sevenfold) as compared to patients without abscess (n = 17). Receiver operation characteristics (ROC) analyses demonstrated that TLG (calculated as MV × SURmean, i.e. TLG (SUR)) had the most favorable area under the ROC curve (0.841 [CI 0.659 to 1.000]) in predicting IE-related abscess formation. This resulted in a sensitivity of 80% and a specificity of 88% at a cut-off value of 14.14 mL for TLG (SUR). Conclusion: We suggest that 18F-FDG PET/CT-derived quantitative assessment of TLG (SUR) may provide a novel diagnostic tool in predicting endocarditis-associated abscess formation.

Details

Original languageEnglish
Pages (from-to)2400-2414
Number of pages15
JournalJournal of Nuclear Cardiology
Volume30
Issue number6
Publication statusPublished - Dec 2023
Peer-reviewedYes

External IDs

PubMed 37264215

Keywords

Keywords

  • F-FDG PET/CT, infective endocarditis, total lesion glycolysis, valve abscess