18F-FDG for the staging of patients with differentiated thyroid cancer: Comparison of a dual-head coincidence gamma camera with dedicated PET

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • Claudia Tiepolt - , Medical Faculty Carl Gustav Carus (Author)
  • Bettina Beuthien-Baumann - , Medical Faculty Carl Gustav Carus, Helmholtz-Zentrum Dresden-Rossendorf (Author)
  • Reiner Hliscs - , Medical Faculty Carl Gustav Carus (Author)
  • Jan Bredow - , Medical Faculty Carl Gustav Carus, Helmholtz-Zentrum Dresden-Rossendorf (Author)
  • Anneliese Kuhne - , Medical Faculty Carl Gustav Carus (Author)
  • Joachim Kropp - , Medical Faculty Carl Gustav Carus (Author)
  • Wolfgang Burchert - , Medical Faculty Carl Gustav Carus, Helmholtz-Zentrum Dresden-Rossendorf (Author)
  • Wolf Gunter Franke - , Medical Faculty Carl Gustav Carus (Author)

Abstract

Coincidence imaging with a dual-head gamma camera may offer a cost-effective alternative to dedicated PET. The aim of this study was to compare the diagnostic accuracy of coincidence imaging and PET in patients with differentiated thyroid cancer. Thirty-one patients were studied after thyroidectomy and radioiodine ablation. They were injected with a single dose of 300 MBq 18F-FDG. Scanning was performed on a dedicated PET system after 1 hr, and on a coincidence gamma camera after 4 hrs. Based on a lesion-by-lesion comparison, coincidence imaging and PET concurred in 69% of 118 lesions. Based on lesion size, concurrence was 96% in lesions larger than 1.5 cm, and 62% in those between 1 and 1.5 cm. Lesions smaller than 1 cm could not be identified with coincidence imaging. Identical staging was obtained with coincidence imaging and PET in 26/31 patients (84%). In four patients FDG accumulating lesions were shown by both the coincidence camera and the dedicated scanner, but not detectable with any other imaging means and were confirmed histologically on surgery. Although a coincidence camera is technically inferior to a dedicated PET scanner, it may provide clinically useful results in situations were a lesion of sufficient size and FDG uptake is to be expected, e.g. when evaluating a known lesion for malignancy.

Details

Original languageEnglish
Pages (from-to)339-345
Number of pages7
JournalAnnals of nuclear medicine : ANN
Volume14
Issue number5
Publication statusPublished - 2000
Peer-reviewedYes

External IDs

PubMed 11108162

Keywords

Sustainable Development Goals

Keywords

  • F-fluorodeoxyglucose, Coincidence imaging, Differentiated thyroid cancer, Positron emission tomography