18F-FDG for the staging of patients with differentiated thyroid cancer: Comparison of a dual-head coincidence gamma camera with dedicated PET
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
Coincidence imaging with a dual-head gamma camera may offer a cost-effective alternative to dedicated PET. The aim of this study was to compare the diagnostic accuracy of coincidence imaging and PET in patients with differentiated thyroid cancer. Thirty-one patients were studied after thyroidectomy and radioiodine ablation. They were injected with a single dose of 300 MBq 18F-FDG. Scanning was performed on a dedicated PET system after 1 hr, and on a coincidence gamma camera after 4 hrs. Based on a lesion-by-lesion comparison, coincidence imaging and PET concurred in 69% of 118 lesions. Based on lesion size, concurrence was 96% in lesions larger than 1.5 cm, and 62% in those between 1 and 1.5 cm. Lesions smaller than 1 cm could not be identified with coincidence imaging. Identical staging was obtained with coincidence imaging and PET in 26/31 patients (84%). In four patients FDG accumulating lesions were shown by both the coincidence camera and the dedicated scanner, but not detectable with any other imaging means and were confirmed histologically on surgery. Although a coincidence camera is technically inferior to a dedicated PET scanner, it may provide clinically useful results in situations were a lesion of sufficient size and FDG uptake is to be expected, e.g. when evaluating a known lesion for malignancy.
Details
Original language | English |
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Pages (from-to) | 339-345 |
Number of pages | 7 |
Journal | Annals of nuclear medicine : ANN |
Volume | 14 |
Issue number | 5 |
Publication status | Published - 2000 |
Peer-reviewed | Yes |
External IDs
PubMed | 11108162 |
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Keywords
Sustainable Development Goals
ASJC Scopus subject areas
Keywords
- F-fluorodeoxyglucose, Coincidence imaging, Differentiated thyroid cancer, Positron emission tomography