Transcriptional Levels of Intercellular Junction Proteins in an Alveolar Epithelial Cell Line Exposed to Irradiation or Bleomycin
Publikation: Beitrag in Fachzeitschrift › Forschungsartikel › Beigetragen › Begutachtung
Beitragende
Abstract
We performed a comparative study of the effects of X-ray irradiation and bleomycin on the mRNA levels of E-cadherin and tight junction proteins (claudin-3, claudin-4, claudin-18, ZO-2, and occludin) in an alveolar epithelial cell line L2. Irradiation decreased claudin-4 levels and increased occludin levels, while the levels of other mRNAs remained unchanged. Bleomycin increased the expression levels of all proteins examined except claudin-3. Irradiation and bleomycin have different effects on the expression level of intercellular junction proteins, indicating different reactions triggered in alveolar epithelial cells and a great prospects of further comparative studies.
Details
Originalsprache | Englisch |
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Seiten (von - bis) | 442-446 |
Seitenumfang | 5 |
Fachzeitschrift | Bulletin of Experimental Biology and Medicine |
Jahrgang | 176 |
Ausgabenummer | 4 |
Publikationsstatus | Veröffentlicht - Feb. 2024 |
Peer-Review-Status | Ja |
Externe IDs
PubMed | 38488962 |
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ORCID | /0000-0003-3953-3253/work/158306270 |
Schlagworte
ASJC Scopus Sachgebiete
Schlagwörter
- E-cadherin, bleomycin, cell line L2, irradiation, tight junctions, Claudin-3/metabolism, Occludin/genetics, Epithelial Cells, Bleomycin/pharmacology, Intercellular Junctions/metabolism, RNA, Messenger/genetics, Zonula Occludens-1 Protein/metabolism, Tight Junctions/metabolism, Alveolar Epithelial Cells/metabolism, Claudin-4/metabolism