Tract based spatial statistic reveals no differences in white matter microstructural organization between carriers and non-carriers of the APOE ε4 and ε2 alleles in young healthy adolescents
Publikation: Beitrag in Fachzeitschrift › Forschungsartikel › Beigetragen › Begutachtung
Beitragende
- King's College London (KCL)
- Zentralinstitut für Seelische Gesundheit (ZI)
- Universität Heidelberg
- Trinity College Dublin
- Universität Hamburg
- University of Montreal
- Commissariat à l’énergie atomique et aux énergies alternatives (CEA)
- University of Vermont
- University of Nottingham
- Charité – Universitätsmedizin Berlin
- INSERM - Institut national de la santé et de la recherche médicale
- University of Toronto
- Centre Universitaire de Sante McGill
- Karolinska Institutet
Abstract
The apolipoprotein E (APOE) ε4 allele is the best established genetic risk factor for Alzheimer's disease (AD) and has been previously associated with alterations in structural gray matter and changes in functional brain activity in healthy middle-aged individuals and older non-demented subjects. In order to determine the neural mechanism by which APOE polymorphisms affect white matter (WM) structure, we investigated the diffusion characteristics of WM tracts in carriers and non-carriers of the APOE ε4 and ε2 alleles using an unbiased whole brain analysis technique (Tract Based Spatial Statistics) in a healthy young adolescent (14 years) cohort. A large sample of healthy young adolescents (n = 575) were selected from the European neuro imaging-genetics IMAGEN study with available APOE status and accompanying diffusion imaging data. MR Diffusion data was acquired on 3T systems using 32 diffusion-weighted (DW) directions and 4 non-DW volumes (b-value = 1,300 s/mm2 and isotropic resolution of 2.4×2.4×2.4 mm). No significant differences in WM structure were found in diffusion indices between carriers and non-carriers of the APOE ε4 and ε2 alleles, and dose-dependent effects of these variants were not established, suggesting that differences in WM structure are not modulated by the APOE polymorphism. In conclusion, our results suggest that microstructural properties of WM structure are not associated with the APOE ε4 and ε2 alleles in young adolescence, suggesting that the neural effects of these variants are not evident in 14-year-olds and may only develop later in life.
Details
Originalsprache | Englisch |
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Seiten (von - bis) | 977-984 |
Seitenumfang | 8 |
Fachzeitschrift | Journal of Alzheimer's disease |
Jahrgang | 47 |
Ausgabenummer | 4 |
Publikationsstatus | Veröffentlicht - 11 Aug. 2015 |
Peer-Review-Status | Ja |
Externe IDs
PubMed | 26401776 |
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ORCID | /0000-0001-5398-5569/work/161890703 |
Schlagworte
ASJC Scopus Sachgebiete
Schlagwörter
- Apolipoprotein E, Diffusion tensor imaging, Magnetic resonance imaging, Tract based spatial statistics, Young healthy adolescents