The Role of Polymorphisms at the Interleukin-1, Interleukin-4, GATA-3 and Cyclooxygenase-2 Genes in Non-Surgical Periodontal Therapy

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung


  • Kay Arne Walther - , Justus Liebig University Giessen (Autor:in)
  • José Roberto Gonzales - , Justus Liebig University Giessen (Autor:in)
  • Sabine Gröger - , Justus Liebig University Giessen (Autor:in)
  • Benjamin Ehmke - , Westfälische Wilhelms-Universität Münster (Autor:in)
  • Dogan Kaner - , Charité – Universitätsmedizin Berlin, Witten/Herdecke University (Autor:in)
  • Katrin Lorenz - , Poliklinik für Parodontologie (Autor:in)
  • Peter Eickholz - , Universitätsklinikum Frankfurt (Autor:in)
  • Thomas Kocher - , Ernst-Moritz-Arndt-Universität Greifswald (Autor:in)
  • Ti Sun Kim - , Universität Heidelberg (Autor:in)
  • Ulrich Schlagenhauf - , Julius-Maximilians-Universität Würzburg (Autor:in)
  • Raphael Koch - , Westfälische Wilhelms-Universität Münster (Autor:in)
  • Jörg Meyle - , Justus Liebig University Giessen (Autor:in)


Periodontitis is a multifactorial disease. The aim of this explorative study was to investigate the role of Interleukin-(IL)-1, IL-4, GATA-3 and Cyclooxygenase-(COX)-2 polymorphisms after non-surgical periodontal therapy with adjunctive systemic antibiotics (amoxicillin/metronidazole) and subsequent maintenance in a Caucasian population. Analyses were performed using blood samples from periodontitis patients of a multi-center trial ( NCT00707369=ABPARO-study). Polymorphisms were analyzed using quantitative real-time PCR. Clinical attachment levels (CAL), percentage of sites showing further attachment loss (PSAL) ≥1.3 mm, bleeding on probing (BOP) and plaque score were assessed. Exploratory statistical analysis was performed. A total of 209 samples were genotyped. Patients carrying heterozygous genotypes and single-nucleotide-polymorphisms (SNP) on the GATA-3-IVS4 +1468 gene locus showed less CAL loss than patients carrying wild type. Heterozygous genotypes and SNPs on the IL-1A-889, IL-1B +3954, IL-4-34, IL-4-590, GATA-3-IVS4 +1468 and COX-2-1195 gene loci did not influence CAL. In multivariate analysis, CAL was lower in patients carrying GATA-3 heterozygous genotypes and SNPs than those carrying wild-types. For the first time, effects of different genotypes were analyzed in periodontitis progression after periodontal therapy and during supportive treatment using systemic antibiotics demonstrating a slight association of GATA-3 gene locus with CAL. This result suggests that GATA-3 genotypes are a contributory but non-essential risk factor for periodontal disease progression.


FachzeitschriftInternational journal of molecular sciences
PublikationsstatusVeröffentlicht - 1 Juli 2022

Externe IDs

PubMed 35806269
ORCID /0000-0002-0228-6140/work/146167269



  • antibiotics, Cyclooxygenase-2, GATA-3, Interleukin-1, Interleukin-4, periodontal therapy, periodontitis, polymorphisms, risk factor