The paper presents the analysis of hot deformation behavior of Ti-6Al-2Sn-4Zr-6Mo (Ti-6246) alloy using the theory of dynamic material modeling (DMM) based on hot compression tests performed to a total true strain of 1 at the strain rates from 0.01 to 100 s⁻¹ and at the temperatures within the range between 800 and 1100 °C. The processing maps according to the Prasad’s criterion were developed. The analysis of the processing maps allowed for the placement of domains describing the areas of potentially favorable combinations of hot deformation parameters. The microstructure observations of the investigated alloy specimens after hot deformation in stability and instability areas were conducted. The optimal processing parameters for numerical modeling of Ti-6246 alloy forging were selected based on processing maps. After complex analysis of the obtained results, microstructural observations and numerical modeling of forging of selected part, the forging tests of Ti-6246 alloy were realized. The obtained product quality assessment was carried out by computed tomography non-destructive testing.