Staphylococcus aureus extracellular adherence protein serves as anti-inflammatory factor by inhibiting the recruitment of host leukocytes
Publikation: Beitrag in Fachzeitschrift › Forschungsartikel › Beigetragen › Begutachtung
Beitragende
Abstract
Staphylococcus aureus is a human pathogen that secretes proteins that contribute to bacterial colonization. Here we describe the extracellular adherence protein (Eap) as a novel anti-inflammatory factor that inhibits host leukocyte recruitment. Due to its direct interactions with the host adhesive proteins intercellular adhesion molecule 1 (ICAM-1), fibrinogen or vitronectin, Eap disrupted beta(2)-integrin and urokinase receptor mediated leukocyte adhesion in vitro. Whereas Eap-expressing S. aureus induced a 2 3-fold lower neutrophil recruitment in bacterial peritonitis in mice as compared with an Eap-negative strain, isolated Eap prevented beta(2)-integrin-dependent neutrophil recruitment in a mouse model of acute thioglycollate-induced peritonitis. Thus, the specific interactions with ICAM-1 and extracellular matrix proteins render Eap a potent anti-inflammatory factor, which may serve as a new therapeutic substance to block leukocyte extravasation in patients with hyperinflammatory pathologies.
Details
Originalsprache | Englisch |
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Seiten (von - bis) | 687-693 |
Seitenumfang | 7 |
Fachzeitschrift | Nature medicine |
Jahrgang | 8 |
Ausgabenummer | 7 |
Publikationsstatus | Veröffentlicht - Juli 2002 |
Peer-Review-Status | Ja |
Extern publiziert | Ja |
Externe IDs
Scopus | 0036061581 |
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Schlagworte
Schlagwörter
- Animals, Anti-Inflammatory Agents, Non-Steroidal/pharmacology, Bacterial Adhesion, Bacterial Proteins/pharmacology, Cell Adhesion/drug effects, Cell Line, Endothelium, Vascular/microbiology, Fibronectins/physiology, Humans, Intercellular Adhesion Molecule-1/physiology, Leukocytes/microbiology, Macrophage-1 Antigen/physiology, Mice, Mice, Inbred Strains, Peritonitis/microbiology, Staphylococcal Infections/microbiology, Staphylococcus aureus/physiology, U937 Cells, Umbilical Veins