The past decade has shown a great advancement towards full network softwarization. In particular, the arrival of software-defined networking (SDN) and network function virtualization (NFV) is transforming network management and design approaches. SDN decouples the network control function from a forwarding function to centralize it with a global view of the network. This approach also is used to program the network from the central controller using the global view of the network instead of configuring individual routers as in the classic method. NFV is the softwarization of network functions such as firewalls, NAT, deep packet inspection, etc. The softwarization of networks along with the flexibility of the programmable networks would pave the way for intelligent networks that could suit remote and space communication. In particular, network softwarization is enabling a 3D network with a potential application for lunar and Martian deployment interconnecting them with the territorial global connectivity. This chapter discusses network softwarization and intelligence in the context of space exploration while also identifying possible research challenges and future directions.