This article reviews the efficacy of couple-based, cognitive-behavioral interventions for psychopathology. Over the past two decades, cognitive-behavioral couples therapy has been adapted and systematically integrated with individual cognitive-behavioral therapy for the treatment of a range of individual mental disorders. These integrated approaches are distinct from typical couples therapy and serve as psychotherapy interventions with a primary focus on the disorder, while incorporating partners in the treatment. The article introduces core concepts of couples-based interventions and reviews the findings of clinical trials. Overall, clinical trials of couple-based interventions for depression, substance-use disorders, anxiety disorders, obsessive-compulsive disorder, posttraumatic stress disorder, and eating disorders show significant symptom improvements that are always at least as large and often larger than that found in individual treatments where a comparison is available. Additionally, couple-based interventions often have significant positive effects on relationship satisfaction as well as interpersonal risk factors for adverse treatment outcomes and relapse such as expressed emotion and symptom accommodation. Further randomized controlled trials are needed to provide a direct comparison with individual cognitive behavioral therapy for several disorders and to pinpoint factors that support clinical decision making to recommend an individual versus couple-based treatment. Finally, clinical recommendations are summarized briefly.