Oogenesis: Ageing Oocyte Chromosomes Rely on Amazing Protein Stability
Publikation: Beitrag in Fachzeitschrift › Forschungsartikel › Beigetragen › Begutachtung
Beitragende
Abstract
Meiotic chromosome segregation in mouse oocytes seems to rely on highly stable cohesins and CENP-A produced in the fetus and not replenished during postnatal life. Hence, demise of these proteins may underpin declining oocyte quality in ageing mammals and thus marks a major problem of reproductive health in humans.
Details
Originalsprache | Englisch |
---|---|
Seiten (von - bis) | R329-31 |
Fachzeitschrift | Current Biology |
Jahrgang | 26 |
Ausgabenummer | 8 |
Publikationsstatus | Veröffentlicht - 25 Apr. 2016 |
Peer-Review-Status | Ja |
Externe IDs
Scopus | 84964997235 |
---|---|
PubMed | 27115691 |
Schlagworte
Schlagwörter
- Aging, Animals, Chromosomes, Humans, Meiosis, Mice, Oocytes, Oogenesis, Protein Stability