Oogenesis: Ageing Oocyte Chromosomes Rely on Amazing Protein Stability
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
Meiotic chromosome segregation in mouse oocytes seems to rely on highly stable cohesins and CENP-A produced in the fetus and not replenished during postnatal life. Hence, demise of these proteins may underpin declining oocyte quality in ageing mammals and thus marks a major problem of reproductive health in humans.
Details
| Original language | English |
|---|---|
| Pages (from-to) | R329-31 |
| Journal | Current Biology |
| Volume | 26 |
| Issue number | 8 |
| Publication status | Published - 25 Apr 2016 |
| Peer-reviewed | Yes |
External IDs
| Scopus | 84964997235 |
|---|---|
| PubMed | 27115691 |
Keywords
Keywords
- Aging, Animals, Chromosomes, Humans, Meiosis, Mice, Oocytes, Oogenesis, Protein Stability