In 2019, the National Center for Tumor Diseases (NCT/UCC) at the University Hospital Dresden launched the Onco-Patforms program, funded by the German Cancer Aid Center of Excellence Program. This initiative enables electronic collection of patient-reported outcomes (PROs) for use in clinical decision-making. We describe the implementation process at the interdisciplinary outpatient clinic of the NCT/UCC, share experiences from 2019 to 2024, and outline the conclusions drawn. Over nearly 6 years of the project’s duration, numerous adjustments have been made, both in terms of content and purpose as well as in terms of technical and staffing structures. Screening has consistently focused on supportive needs, initially concentrating on psychooncology and later expanding to include exercise therapy, smoking cessation programs, social services, and nutritional counseling. Since 2023, patients with multiple support needs have been discussed in a supportive tumor board. Since the project began, 3543 screenings have been conducted; in 2024, the average number of screenings per month was 138, with a coverage rate exceeding 50% in the target population. During the 13 months of the tumor board’s operation, 259 patients have been discussed and 380 recommendations issued. The establishment of ePRO routine screening at our center of excellence is an ongoing process aimed at achieving needs-based patient care.