Multi-parametric hydrogels support 3D invitro bioengineered microenvironment models of tumour angiogenesis
Publikation: Beitrag in Fachzeitschrift › Forschungsartikel › Beigetragen › Begutachtung
Beitragende
Abstract
Tumour microenvironment greatly influences the development and metastasis of cancer progression. The development of three dimensional (3D) culture models which mimic that displayed invivo can improve cancer biology studies and accelerate novel anticancer drug screening. Inspired by a systems biology approach, we have formed 3D invitro bioengineered tumour angiogenesis microenvironments within a glycosaminoglycan-based hydrogel culture system. This microenvironment model can routinely recreate breast and prostate tumour vascularisation. The multiple cell types cultured within this model were less sensitive to chemotherapy when compared with two dimensional (2D) cultures, and displayed comparative tumour regression to that displayed invivo. These features highlight the use of our invitro culture model as a complementary testing platform in conjunction with animal models, addressing key reduction and replacement goals of the future. We anticipate that this biomimetic model will provide a platform for the in-depth analysis of cancer development and the discovery of novel therapeutic targets.
Details
Originalsprache | Englisch |
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Seiten (von - bis) | 609-620 |
Seitenumfang | 12 |
Fachzeitschrift | Biomaterials |
Jahrgang | 53 |
Publikationsstatus | Veröffentlicht - 1 Juni 2015 |
Peer-Review-Status | Ja |
Externe IDs
PubMed | 25890757 |
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ORCID | /0000-0003-0189-3448/work/161890459 |
Schlagworte
ASJC Scopus Sachgebiete
Schlagwörter
- Angiogenesis, Carcinogenesis, Cell culture, ECM, Heparin, Hydrogel