3D-reinforcements such as Z-pins can improve the delamination strength of composites substantially. They are thus of significant interest for safety critical thick composite structures. For structural applications the effect of fatigue on these 3D-reinforcements needs to be investigated to assess the behaviour of a Z-pinned component after being in service for a while or after a major impact event has taken place. Here the findings from a previous micro mechanical study characterising the behaviour of Z-pins under various fatigue loading conditions are transferred into an analytical/numerical model and validated with bespoke meso scale DCB and ELS tests. Good agreement between simulation and experiment was found for most load cases, however, the model seems slightly to overpredict the degradation in mode I loading scenarios for small amplitudes and medium average pin displacements.