Model evaluation for glycolytic oscillations in yeast biotransformations of xenobiotics

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • L Brusch - , Institut national des sciences appliquées de Toulouse (INSA), Max-Planck-Institute for the Physics of Complex Systems (Autor:in)
  • G Cuniberti - , Max-Planck-Institute for the Physics of Complex Systems, Universität Regensburg (Autor:in)
  • Martin Bertau - , Technische Universität Dresden (Autor:in)

Abstract

Anaerobic glycolysis in yeast perturbed by the reduction of xenobiotic ketones is studied numerically in two models which possess the same topology but different levels of complexity. By comparing both models' predictions for concentrations and fluxes as well as steady or oscillatory temporal behavior we answer the question what phenomena require what kind of minimum model abstraction. While mean concentrations and fluxes are predicted in agreement by both models we observe different domains of oscillatory behavior in parameter space. Generic properties of the glycolytic response to ketones are discussed. (C) 2003 Elsevier B.V. All rights reserved.

Details

OriginalspracheEnglisch
Seiten (von - bis)413-426
Seitenumfang14
FachzeitschriftBiophysical chemistry
Jahrgang109
Ausgabenummer3
PublikationsstatusVeröffentlicht - 1 Juni 2004
Peer-Review-StatusJa
Extern publiziertJa

Externe IDs

Scopus 1942508726
ORCID /0000-0003-0137-5106/work/142244242

Schlagworte

Schlagwörter

  • glycolysis, metabolic oscillations, model, biotransformation, BAKERS-YEAST, SACCHAROMYCES-CEREVISIAE, REDUCTION, DYNAMICS, CALCIUM, ESTERS, NETWORKS, ENZYMES