Lithium Response in Bipolar Disorder is Associated with Focal Adhesion and PI3K-Akt Networks: A Multi-omics Replication Study

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • John Kelsoe - , University of California at San Diego (Autor:in)
  • Anna Ou - , University of California at San Diego (Autor:in)
  • Sara Rosenthal - (Autor:in)
  • Mazda Adli - (Autor:in)
  • Kazufumi Akiyama - , Dokkyo Medical University (Autor:in)
  • Nirmala Akula - , National Institutes of Health (NIH) (Autor:in)
  • Martin Alda - , Dalhousie University (Autor:in)
  • Azmeraw T Amare - , Royal Adelaide Hospital (Autor:in)
  • Raffaella Ardau - , Hospital University Agency of Cagliari (Autor:in)
  • Bárbara Arias - , Facultat de Biologia and Institut de Biomedicina (IBUB) (Autor:in)
  • Jean-Michel Aubry - , Hôpitaux universitaires de Genève (Autor:in)
  • Lena Backlund - (Autor:in)
  • Claudio Banzato - (Autor:in)
  • Michael Bauer - , Klinik und Poliklinik für Psychiatrie und Psychotherapie, Technische Universität Dresden, Hochschulmedizin (Medizinische Fakultät und Universitätsklinikum) (Autor:in)
  • Bernhard Baune - , Universitätsklinikum Münster (Autor:in)
  • Frank Bellivier - (Autor:in)
  • Antonio Benabarre - (Autor:in)
  • Susanne Bengesser - (Autor:in)
  • Bhattacharjee Abesh - (Autor:in)
  • Joanna Biernacka - , Mayo Clinic Rochester, MN (Autor:in)
  • Elise Bui - (Autor:in)
  • Pablo Cervantes - , McGill University (Autor:in)
  • Guo-Bo Chen - (Autor:in)
  • Hsi-Chung Chen - , National Taiwan University Hospital (Autor:in)
  • Caterina Chillotti - (Autor:in)
  • Sven Cichon - , Mayo Clinic Rochester, MN (Autor:in)
  • Scott Clark - , Royal Adelaide Hospital (Autor:in)
  • Francesc Colom - (Autor:in)
  • David Cousins - (Autor:in)
  • Cristiana Cruceanu - , Max Planck Institute of Psychiatry (Autor:in)
  • Piotr Czerski - , University of Medical Sciences Poznan (Autor:in)
  • Clarissa Dantas - (Autor:in)
  • Alexandre Dayer - , University of Geneva (Autor:in)
  • Franziska Degenhardt - , Universitätsklinikum Essen (Autor:in)
  • J Raymond DePaulo - , Johns Hopkins University (Autor:in)
  • Bruno Etain - (Autor:in)
  • Peter Falkai - , Klinikum der Ludwig-Maximilians-Universität (LMU) München (Autor:in)
  • Frederike Fellendorf - (Autor:in)
  • Ewa Ferensztajn-Rochowiak - (Autor:in)
  • Andreas J Forstner - , Universitätsklinikum Bonn (Autor:in)
  • Louise Frisen - , Universitätsklinikum Bonn (Autor:in)
  • Mark Frye - , Mayo Clinic Rochester, MN (Autor:in)
  • Janice Fullerton - , Neuroscience Research Australia (Autor:in)
  • Sebastien Gard - (Autor:in)
  • Julie Garnham - (Autor:in)
  • Fernando Goes - (Autor:in)
  • Maria Grigoroiu-Serbanescu - , Alexandru Obregia Clinical Psychiatric Hospital (Autor:in)
  • Paul Grof - (Autor:in)
  • Oliver Gruber - (Autor:in)
  • Ryota Hashimoto - , National Center of Neurology and Psychiatry Kodaira (Autor:in)
  • Joanna Hauser - (Autor:in)
  • Urs Heilbronner - , Basurto University Hospital (Autor:in)
  • Stefan Herms - (Autor:in)
  • Per Hoffmann - , Maine Institute for Human Genetics and Health (Autor:in)
  • Andrea Hofmann - (Autor:in)
  • Liping Hou - , National Institutes of Health (NIH) (Autor:in)
  • Stéphane Jamain - , Univ Paris Est Creteil (Autor:in)
  • Esther Jiménez - (Autor:in)
  • Jean-Pierre Kahn - (Autor:in)
  • Layla Kassem - , Universitätsklinikum Bonn (Autor:in)
  • Tadafumi Kato - , Juntendo University Graduate School of Medicine (Autor:in)
  • Sarah Kittel-Schneider - (Autor:in)
  • Barbara König - (Autor:in)
  • Po-Hsiu Kuo - , National Taichung University of Education (Autor:in)
  • Ichiro Kusumi - , Hokkaido University Graduate School of Medicine (Autor:in)
  • Nina Dalkner - (Autor:in)
  • Gonzalo Laje - (Autor:in)
  • Mikael Landén - , University of Gothenburg (Autor:in)
  • Catharina Lavebratt - , Karolinska Institutet (Autor:in)
  • Marion Leboyer - (Autor:in)
  • Susan Leckband - (Autor:in)
  • Carlos López Jaramillo - (Autor:in)
  • Glenda MacQueen - (Autor:in)
  • Mario Maj - , University of Naples Federico II (Autor:in)
  • Mirko Manchia - , Dalhousie University (Autor:in)
  • Cynthia Marie-Claire - , INSERM UMR-S 1144. (Autor:in)
  • Lina Martinsson - , Karolinska Institutet (Autor:in)
  • Manuel Mattheisen - , Johns Hopkins University (Autor:in)
  • Michael McCarthy - (Autor:in)
  • Susan McElroy - , Lindner Center (Autor:in)
  • Francis McMahon - , National Institutes of Health (NIH) (Autor:in)
  • Philip Mitchell - , University of New South Wales (Autor:in)
  • Marina Mitjans - , Max Planck Institute of Experimental Medicine (Autor:in)
  • Francis Mondimore - , Neuroscience Research Australia (Autor:in)
  • Palmiero Monteleone - , University of Salerno (Autor:in)
  • Caroline Nievergelt - , University of California at Irvine (Autor:in)
  • Markus Nöthen - , Universitätsklinikum Bonn (Autor:in)
  • Tomas Novak - , National Institute of Mental Health (Autor:in)
  • Urban Osby - , Karolinska Institutet (Autor:in)
  • Norio Ozaki - , Nagoya University (Autor:in)
  • Sergi Papiol - , Klinikum der Ludwig-Maximilians-Universität (LMU) München (Autor:in)
  • Roy Perlis - , Massachusetts General Hospital (Autor:in)
  • Andrea Pfennig - , Klinik und Poliklinik für Psychiatrie und Psychotherapie, Technische Universität Dresden, Universitätsklinikum Carl Gustav Carus Dresden (Autor:in)
  • James Potash - (Autor:in)
  • Daniela Reich-Erkelenz - (Autor:in)
  • Andreas Reif - , Universitätsklinikum Frankfurt (Autor:in)
  • Eva Reininghaus - (Autor:in)
  • Marcella Rietschel - , Universitätsklinikum Mannheim (Autor:in)
  • Guy Rouleau - , McGill University (Autor:in)
  • Janusz K Rybakowski - , University of Medical Sciences Poznan (Autor:in)
  • Martin Schalling - , Karolinska Institutet (Autor:in)
  • Peter Schofield - , Neuroscience Research Australia (Autor:in)
  • Klaus Oliver Schubert - , Royal Adelaide Hospital (Autor:in)
  • Thomas Schulze - , Professur für Maschinenelemente, Technische Universität München (Autor:in)
  • Barbara Schweizer - (Autor:in)
  • Florian Seemüller - (Autor:in)
  • Giovanni Severino - , University Hospital of Cagliari (Autor:in)
  • Tatyana Shekhtman - (Autor:in)
  • Paul Shilling - (Autor:in)
  • Kazutaka Shimoda - (Autor:in)
  • Christian Simhandl - (Autor:in)
  • Claire Slaney - (Autor:in)
  • Alessio Squassina - , Università degli Studi di Cagliari (Autor:in)
  • Thomas Stamm - , Charité – Universitätsmedizin Berlin (Autor:in)
  • Pavla Stopkova - (Autor:in)
  • Sarah Tighe - (Autor:in)
  • Alfonso Tortorella - , University Hospital of Perugia (Autor:in)
  • Gustavo Turecki - , McGill University (Autor:in)
  • Eduard Vieta - , Hospital Clínic de Barcelona (Autor:in)
  • Julia Volkert - (Autor:in)
  • Stephanie Witt - , University Medical Centre Mannheim (Autor:in)
  • Naomi Wray - , University of Queensland (Autor:in)
  • Adam Wright - (Autor:in)
  • Trevor Young - (Autor:in)
  • Peter Zandi - , Johns Hopkins University (Autor:in)
  • Maria Del Zompo - , University Hospital of Cagliari (Autor:in)

Abstract

Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of action is incompletely understood, and prediction of treatment outcomes is limited. In our previous multi-omics study of the Pharmacogenomics of Bipolar Disorder (PGBD) sample combining transcriptomic and genomic data, we found that focal adhesion, the extracellular matrix (ECM), and PI3K-Akt signaling networks were associated with response to lithium. In this study, we replicated the results of our previous study using network propagation methods in a genome-wide association study of an independent sample of 2,039 patients from the International Consortium on Lithium Genetics (ConLiGen) study. We identified functional enrichment in focal adhesion and PI3K-Akt pathways, but we did not find an association with the ECM pathway. Our results suggest that deficits in the neuronal growth cone and PI3K-Akt signaling, but not in ECM proteins, may influence response to lithium in BD.

Details

OriginalspracheEnglisch
FachzeitschriftResearch Square
PublikationsstatusVeröffentlicht - 3 Okt. 2023
Peer-Review-StatusJa

Externe IDs

PubMedCentral PMC10602152
unpaywall 10.21203/rs.3.rs-3258813/v1
ORCID /0000-0002-2666-859X/work/146643986
ORCID /0000-0002-3415-5583/work/150329708

Schlagworte