Digitalization confronts organizations with huge challenges and opportunities. With all economic and societal sectors being affected by emerging technologies, the digital economy is highly volatile, uncertain, complex, and ambiguous. Against this backdrop, this book reports on the best practices and lessons learned from organizations that succeeded in tackling the challenges and seizing the opportunities of the digital economy on a global scale. It illustrates how 20 organizations leveraged their capabilities to create disruptive innovation, to develop digital business models and to digitally transform themselves. These cases stem from various geographical regions and industries, covering the many facets that digitalization may have.