Lightweight design by using low-density and load-adapted materials can reduce the weight of vehicles and the emissions generated during operation. However, the usage of different materials requires innovative joining technologies with increased versatility. In this investigation, the focus is on describing and characterising the failure behaviour of connections manufactured by an innovative thermomechanical joining process with adaptable auxiliary joining elements in single-lap tensile-shear tests. In order to analyse the failure development in detail, the specimens are investigated using in-situ computed tomography (in-situ CT). Here, the tensile-shear test is interrupted at points of interest and CT scans are conducted under load. In addition, the interrupted in-situ testing procedure is validated by comparing the loading behaviour with conventional continuous tensile-shear tests. The results of the in-situ investigations of joints with varying material combinations clearly describe the cause of failure, allowing conclusions towards an improved joint design.