Impact of blood perilipin A levels on obesity and metabolic health

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Emmanuel K Ofori - , University of Ghana (Autor:in)
  • Bright Selorm Letsu - , University of Ghana (Autor:in)
  • Seth K Amponsah - , University of Ghana (Autor:in)
  • John Ahenkorah - , University of Ghana (Autor:in)
  • Sandra Crabbe - , Korle-Bu Teaching Hospital, Accra, Ghana. (Autor:in)
  • Genevieve Kwao-Zigah - , University of Ghana (Autor:in)
  • Sylvester Y Oppong - , International Maritime Hospital, Tema, Ghana. (Autor:in)
  • Patrick Diaba-Nuhoho - , Medizinische Klinik und Poliklinik III, Universitätsklinikum Carl Gustav Carus Dresden (Autor:in)
  • Seth D Amanquah - , University of Ghana (Autor:in)

Abstract

OBJECTIVE: Perilipin A is a common protein that coats lipid surfaces preventing them from being exposed to oxidative damage. Researchers have found little consistency in the relationship between perilipin A levels in the blood and body fat. This study was a cross-sectional observational that looked at circulating perilipin A levels and how they relate to metabolic health.

RESULTS: The participants in this study were 86 individuals with a mean age of 45.5 ± 1.2 years. Multiple clinical and metabolic indicators (age, weight, BMI, total body fat mass, triglyceride, and HOMA-IR) were shown to be inversely associated with perilipin A levels (rho = - 0.32, - 0.37, - 0.40, - 0.45, - 0.33 and - 0.29; p < 0.05 respectively). Obese persons were almost six times more likely than non-obese individuals to have lower perilipin A levels (odds ratio = 6.22, CI = 2.35-11.50, p < 0.001). Our findings underscore the important role of perilipin A proteins in metabolic health.

Details

OriginalspracheEnglisch
Aufsatznummer367
FachzeitschriftBMC Research Notes
Jahrgang15
Ausgabenummer1
PublikationsstatusVeröffentlicht - 12 Dez. 2022
Peer-Review-StatusJa

Externe IDs

PubMedCentral PMC9743615
Scopus 85143785039
ORCID /0000-0002-8672-6640/work/173989375

Schlagworte

Ziele für nachhaltige Entwicklung

Schlagwörter

  • Adult, Body Mass Index, Cross-Sectional Studies, Humans, Insulin Resistance, Middle Aged, Obesity, Perilipin-1