Hematopoietic hypoxia-inducible factor 2 deficiency ameliorates pathological retinal neovascularization via modulation of endothelial cell apoptosis

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

Abstract

A hallmark of proliferative retinopathies, such as retinopathy of prematurity (ROP), is a pathological neovascularization orchestrated by hypoxia and the resulting hypoxia-inducible factor (HIF)-dependent response. Westudiedthe roleofHif2αinhematopoietic cells forpathological retinaneovascularizationinthemurinemodelof ROP, the oxygen-induced retinopathy (OIR) model. Hematopoietic-specific deficiency of Hif2α ameliorated pathological neovascularization in theOIRmodel,whichwas accompanied by enhanced endothelial cell apoptosis. That latter finding was associated with up-regulation of the apoptosis-inducer FasL in Hif2α-deficient microglia. Consistently, pharmacological inhibition of the FasL reversed the reduced pathological neovascularization from hematopoietic-specific Hif2α deficiency. Our study found that the hematopoietic cell Hif2α contributes to pathological retina angiogenesis. Our findings not only provide novel insights regarding the complex interplay between immune cells and endothelial cells in hypoxia-driven retina neovascularization but also may have therapeutic implications for proliferative retinopathies.

Details

OriginalspracheEnglisch
Seiten (von - bis)1758-1770
FachzeitschriftThe FASEB journal
Jahrgang33
Ausgabenummer2
PublikationsstatusVeröffentlicht - Feb. 2019
Peer-Review-StatusJa

Externe IDs

WOS 000457296600020
PubMed 30156910
Scopus 85060912521
ORCID /0000-0002-9467-780X/work/147674932
ORCID /0000-0003-2514-9429/work/148606775

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