Growth induction and low-oxygen apoptosis inhibition of human CD34+ progenitors in collagen gels
Publikation: Beitrag in Fachzeitschrift › Forschungsartikel › Beigetragen › Begutachtung
Beitragende
Abstract
Various reports have indicated low survival of injected progenitors into unfavorable environments such as the ischemic myocardium or lower limb tissues. This represents a major bottleneck in stem-cell-based cardiovascular regenerative medicine. Strategies to enhance survival of these cells in recipient tissues have been therefore sought to improve stem cell survival and ensure long-term engraftment. In the present contribution, we show that embedding human cord blood-derived CD34+ cells into a collagen I-based hydrogel containing cytokines is a suitable strategy to promote stem cell proliferation and protect these cells from anoxia-induced apoptosis.
Details
Originalsprache | Englisch |
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Aufsatznummer | 542810 |
Fachzeitschrift | BioMed research international |
Jahrgang | 2013 |
Publikationsstatus | Veröffentlicht - 2013 |
Peer-Review-Status | Ja |
Externe IDs
PubMed | 23509738 |
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ORCID | /0000-0003-0189-3448/work/161890491 |