This paper investigates the prediction of two-phase gas-liquid flow regimes in both horizontal and slightly inclined pipes. For this purpose, the mechanistic model of Taitel et al. (1976) and the machine learning approach have been adopted. First, the mechanistic model was implemented, tested and optimised by introducing factors in the transition equations to determine the configuration that gives the highest prediction accuracy for a specific two-phase system for which experimental data points are available. Second, several machine learning models are trained, tested and additionally validated. This is done by splitting the experimental data set corresponding to the pipe inclination range (−10^∘ to 10^∘) into training, test and validation sets. The best classifier achieved an accuracy of 95.5% after the test step and up to 98.9% after the validation step. Finally, the Taitel et al. model with the optimal configuration and the best machine learning classifier (XGB classifier) are used to generate the two-dimensional flow regime map.