Karst groundwater vulnerability maps are important tools for the development of groundwater management and protection strategies. However, current methodologies do not always match regional characteristics and parameter adaptations are necessary. In addition, other important processes such as dilution and aquifer residence time are not included in vulnerability analysis for the complications of evaluating two or more criteria simultaneously. The integrated karst aquifer vulnerability approach (IKAV) project aims to develop an integrated approach to include these parameters and estimate global change implications in current and future scenarios. As a first step, intrinsic vulnerability methodologies are studied in order to highlight important parameters and the congruence with regional characteristics of the Yucatan karst. Results demonstrate agreement between methods for the evaluation of high and very high vulnerabilities and their relation with fissures and dolines. Moderate vulnerabilities are assigned to more than 50% of the area. However, moderate vulnerabilities, assigned to the coastal area and the Southern hill, are highly questionable. Intrinsic features affecting moderate classes vary according to the method. Parameter sensitivity analysis and overlap analysis demonstrate the influence of depth to the unsaturated zone, soils, precipitation, and slope on moderate values. Therefore, such parameters must be re-evaluated and discretized according to the characteristics of the study area to match Yucatan regional characteristics.