Enterovirus A71-associated acute flaccid paralysis in a pediatric patient: a case report

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung


Enterovirus A71 is one of the causative agents of hand, foot, and mouth disease, which is usually a self-limiting disease. Complications of enterovirus infection are also very rare. However, when such complications occur, they can lead to serious neurological diseases or even death.

Case presentation
In this report, we describe a case of enterovirus A71-associated acute flaccid paralysis in a 13-month-old Caucasian girl that was managed in our hospital. The patient presented with sudden onset of left arm paresis that could not be attributed to any other cause. Establishing a diagnosis was furthermore complicated by negative virological investigations of cerebrospinal fluid and non-pathological radiological findings. A polymerase chain reaction test of the child’s stool sample however tested positive for enterovirus and sequencing results revealed the presence of enterovirus A71. A previous history of febrile gastroenteritis just before the paresis started also supported the suspected diagnosis of enterovirus-associated acute flaccid paralysis. Following this, the child was treated with intravenous immunoglobulin over 5 days and a remarkable improvement was observed in the child’s paresis.

This case report describes a possible complication of enterovirus A71 infection in a child. It also highlights the prolonged detection of enterovirus in the child’s stool sample as compared with cerebrospinal fluid weeks after the primary infection occurred. Finally, it shows the need for increased clinical and diagnostic awareness especially in the management of sudden and unknown causes of paresis or paralysis in children.


FachzeitschriftJournal of medical case reports
PublikationsstatusVeröffentlicht - 19 Juli 2023

Externe IDs

RIS Akinnurun2023
PubMed 37464446
Mendeley 80391642-57ae-3755-b5f0-6ac0bbf6bfb2
Scopus 85165236716
ORCID /0000-0003-4310-0717/work/142251328


Fächergruppen, Lehr- und Forschungsbereiche, Fachgebiete nach Destatis

Ziele für nachhaltige Entwicklung


  • Female, Child, Humans, Infant, Enterovirus, Enterovirus Infections/complications, Myelitis, Paresis, Enterovirus PCR, Enterovirus A71, Acute flaccid paralysis, Case report, Pediatric infectious diseases