Current practices in the study of biomolecular condensates: a community comment

Publikation: Beitrag in FachzeitschriftKommentar (Comment) / Leserbriefe ohne eigene DatenBeigetragenBegutachtung

Beitragende

  • Simon Alberti - , Professur für Zelluläre Biochemie (Autor:in)
  • Paolo Arosio - , ETH Zürich (Autor:in)
  • Robert B Best - , National Institutes of Health (NIH) (Autor:in)
  • Steven Boeynaems - , Baylor College of Medicine (Autor:in)
  • Danfeng Cai - , Johns Hopkins University (Autor:in)
  • Rosana Collepardo-Guevara - , University of Cambridge (Autor:in)
  • Gregory L Dignon - , Rutgers - The State University of New Jersey, New Brunswick (Autor:in)
  • Rumiana Dimova - , Max-Planck-Institut für Kolloid- und Grenzflächenforschung (Autor:in)
  • Shana Elbaum-Garfinkle - , City University of New York (Autor:in)
  • Nicolas L Fawzi - , Brown University (Autor:in)
  • Monika Fuxreiter - , Università degli studi di Padova (Autor:in)
  • Amy S Gladfelter - , Duke University (Autor:in)
  • Alf Honigmann - , Professur für Biophysik (Autor:in)
  • Ankur Jain - , Whitehead Institute for Biomedical Research (Autor:in)
  • Jerelle A Joseph - , Princeton University (Autor:in)
  • Tuomas P J Knowles - , University of Cambridge (Autor:in)
  • Keren Lasker - , Scripps Research Institute (Autor:in)
  • Edward A Lemke - , Institut für Molekulare Biologie (IMB) gGmbH (Autor:in)
  • Kresten Lindorff-Larsen - , Universität Kopenhagen (Autor:in)
  • Reinhard Lipowsky - , Max-Planck-Institut für Kolloid- und Grenzflächenforschung (Autor:in)
  • Jeetain Mittal - , Texas A&M University (Autor:in)
  • Samrat Mukhopadhyay - , Indian Institute of Science Education and Research Mohali (Autor:in)
  • Sua Myong - , Boston Children's Hospital (Autor:in)
  • Rohit V Pappu - , Washington University St. Louis (Autor:in)
  • Karsten Rippe - , Universität Heidelberg (Autor:in)
  • Tatyana A Shelkovnikova - , University of Sheffield (Autor:in)
  • Anthony G Vecchiarelli - , University of Michigan, Ann Arbor (Autor:in)
  • Susanne Wegmann - , Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) - Standort Berlin (Autor:in)
  • Huaiying Zhang - , Carnegie Mellon University (Autor:in)
  • Mingjie Zhang - , Southern University of Science and Technology (Autor:in)
  • Chloe Zubieta - , Centre national de la recherche scientifique (CNRS) (Autor:in)
  • Markus Zweckstetter - , Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) - Standort Göttingen (Autor:in)
  • Dorothee Dormann - , Institut für Molekulare Biologie (IMB) gGmbH (Autor:in)
  • Tanja Mittag - , St. Jude Children Research Hospital (Autor:in)

Abstract

The realization that the cell is abundantly compartmentalized into biomolecular condensates has opened new opportunities for understanding the physics and chemistry underlying many cellular processes, fundamentally changing the study of biology. The term biomolecular condensate refers to non-stoichiometric assemblies that are composed of multiple types of macromolecules in cells, occur through phase transitions, and can be investigated by using concepts from soft matter physics. As such, they are intimately related to aqueous two-phase systems and water-in-water emulsions. Condensates possess tunable emergent properties such as interfaces, interfacial tension, viscoelasticity, network structure, dielectric permittivity, and sometimes interphase pH gradients and electric potentials–. They can form spontaneously in response to specific cellular conditions or to active processes, and cells appear to have mechanisms to control their size and location–. Importantly, in contrast to membrane-enclosed organelles such as mitochondria or peroxisomes, condensates do not require the presence of a surrounding membrane.

Details

OriginalspracheEnglisch
Aufsatznummer7730
FachzeitschriftNature communications
Jahrgang16
Ausgabenummer1
PublikationsstatusVeröffentlicht - 19 Aug. 2025
Peer-Review-StatusJa

Externe IDs

PubMedCentral PMC12365244
Scopus 105013782623
ORCID /0000-0003-4017-6505/work/191040359
ORCID /0000-0003-0475-3790/work/191041723

Schlagworte