Comparison of inhibitory effects of irbesartan and atorvastatin treatment on the renin angiotensin system (RAS) in veins: A randomized double-blind crossover trial in healthy subjects
Publikation: Beitrag in Fachzeitschrift › Forschungsartikel › Beigetragen › Begutachtung
Abstract
Experimental studies point to an interplay between hyper-cholesterolemia and hypertension, acting through the renin angiotensin system. In a crossover study design with 8 healthy subjects, the authors tested the hypothesis that statin treatment exerts renin angiotensin system-modulating effects in veins by down-regulation of AT1-receptors, resulting in reduced Angiotensin II (Ang II)-induced venoconstriction and by increasing the pleiotropic Ang II-metabolite Ang-(1-7). Irbesartan was used as positive control. Ang II-induced venoconstriction was 49% ± 9% before and 64% ± 10% after 30 days of atorvastatin treatment compared to 50% ± 8% before and 15% ± 9% after irbesartan (P =.004). Plasma angiotensin levels significantly increased only after irbesartan treatment (Ang II: 35 ± 4 vs 329 ± 101 pg/mL [P =.02]; Ang-(1-7): 10 ± 3 vs 35 ± 6 pg/mL [P =.01]) compared to atorvastatin treatment (Ang II: 26 ± 5 vs 31 ± 4 pg/mL [P = ns]; Ang-(1-7): 9 ± 2 vs 11 ± 3 pg/mL [P = ns]). The data indicate that atorvastatin does not inhibit Ang II-induced venoconstriction in vivo and point toward a supportive role of Ang-(1-7) in contributing to the antihypertensive and beneficial vascular effects of irbesartan.
Details
Originalsprache | Englisch |
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Seiten (von - bis) | 112-120 |
Seitenumfang | 9 |
Fachzeitschrift | Journal of Clinical Pharmacology |
Jahrgang | 47 |
Ausgabenummer | 1 |
Publikationsstatus | Veröffentlicht - Jan. 2007 |
Peer-Review-Status | Ja |
Externe IDs
Scopus | 33845783239 |
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PubMed | 17192509 |
researchoutputwizard | legacy.publication#18633 |
ORCID | /0000-0003-1526-997X/work/142247210 |
Schlagworte
ASJC Scopus Sachgebiete
Schlagwörter
- Angiotensin-(1-7), AT1 receptor, Renin angiotensin aldosteron system, Statin, Veins