Bone marrow inflammatory memory in cardiometabolic disease and inflammatory comorbidities

Publikation: Beitrag in FachzeitschriftÜbersichtsartikel (Review)BeigetragenBegutachtung



Cardiometabolic disorders are chief causes of morbidity and mortality, with chronic inflammation playing a crucial role in their pathogenesis. The release of differentiated myeloid cells with elevated pro-inflammatory potential, as a result of maladaptively trained myelopoiesis may be a crucial factor for the perpetuation of inflammation. Several cardiovascular risk factors, including sedentary lifestyle, unhealthy diet, hypercholesterolemia and hyperglycemia, may modulate bone marrow hematopoietic progenitors, causing sustained functional changes that favor chronic metabolic and vascular inflammation. In the present review, we summarize recent studies that support the function of long-term inflammatory memory in progenitors of the bone marrow for development and progression of cardiometabolic disease and related inflammatory comorbidities, including periodontitis and arthritis. We also discuss how maladaptive myelopoiesis associated with the presence of mutated hematopoietic clones, as present in clonal hematopoiesis, may accelerate atherosclerosis via increased inflammation.


FachzeitschriftCardiovascular Research
Frühes Online-Datum19 Jan. 2023
PublikationsstatusVeröffentlicht - 19 Jan. 2023

Externe IDs

PubMed 36655373
WOS 000918475400001
Scopus 85162039026


Forschungsprofillinien der TU Dresden

DFG-Fachsystematik nach Fachkollegium

Ziele für nachhaltige Entwicklung

ASJC Scopus Sachgebiete


  • Cardiovascular risk, Clonal hematopoiesis, Hematopoietic stem and progenitor cells, Trained immunity