Scholars are increasingly examining how the distributed blockchain technology can coun-ter specific supply chain and operations management challenges. Various research approaches emerge from different scholarly backgrounds, but the interrelation of research areas and current trends has not been adequately considered in a systematic review. We employ a data-driven content analysis approach to examine previous research on blockchain technology in operations management and supply chain management. We investigate the extent to which blockchain technology was considered in scholarly works, structure the research efforts, and identify trends, interrelated themes, and promising research opportunities. Quantitative and qualitative content analysis is conducted on an extensive literature sample of 410 articles. Results indicate an optimistic attitude due to potentials such as tracking and tracing abilities, efficiency increases, and trust-building. Conceptual studies dominate the literature set, with increasing qualitative research efforts. Grand theories are seldomly addressed in the studies. Blockchain technology is outlined as particularly useful when combined with other technologies like IoT. We also identified sustainability implications of the tech-nology, such as enabling transparency for SC stakeholders. Cryptocurrencies can facilitate further efficiency gains if legal uncertainties are reduced. The study is concluded with managerial and theoretical implications and future research opportunities.