Beyond lowering circulating LDL: Apheresis-induced changes of systemic oxidative stress markers by four different techniques

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Steffi Kopprasch - , Universitätsklinikum Carl Gustav Carus Dresden, Medizinische Klinik und Poliklinik 3 (Autor:in)
  • Juergen Graessler - , Medizinische Klinik und Poliklinik 3, Universitätsklinikum Carl Gustav Carus Dresden (Autor:in)
  • Stefan R. Bornstein - , Medizinische Klinik und Poliklinik 3, Universitätsklinikum Carl Gustav Carus Dresden (Autor:in)
  • Peter E.H. Schwarz - , Medizinische Klinik und Poliklinik 3, Universitätsklinikum Carl Gustav Carus Dresden (Autor:in)
  • Sergey Tselmin - , Medizinische Klinik und Poliklinik 3, Universitätsklinikum Carl Gustav Carus Dresden (Autor:in)
  • Antje Frind - , Universitätsklinikum Carl Gustav Carus Dresden, Medizinische Klinik und Poliklinik 3 (Autor:in)
  • Ines Poberschin - , Universitätsklinikum Carl Gustav Carus Dresden, Institut für Klinische Chemie und Laboratoriumsmedizin (Autor:in)
  • Ulrich Julius - , Universitätsklinikum Carl Gustav Carus Dresden, Medizinische Klinik und Poliklinik 3 (Autor:in)

Abstract

Objective and methods: Dyslipidemia and oxidative stress are causally related to atherogenesis and cardiovascular disease. We assessed acute changes of systemic oxidative stress biomarkers in thirty-two patients undergoing regular apheresis using four different techniques: heparin-induced extracorporeal LDL precipitation (HELP), direct adsorption of lipoproteins (DALI), lipidfiltration (LF), and immunoadsorption of lipoproteins (IA). Results: All apheresis procedures were similarly effective in lowering LDL cholesterol (-2.5±0.2 mmoL/L), oxidized LDL (-52.4±4.4 U/L), and levels of antioxLDL antibodies (-59.5±15.1 U/L). Among the LDL-apheresis methods investigated, only the DALI technique without prior separation of blood plasma led to a decline in leukocyte count (p=0.01 vs. LF post apheresis) and to decreased phagocyte oxidant-generating activity as evaluated by chemiluminescence. Moreover, DALI was followed by a smaller decrease of blood total antioxidant capacity than the other techniques (p<0.01 vs. HELP post apheresis). Conclusion: Together, our data suggest that compared with other common techniques, the DALI apheresis system is accompanied by the lowest systemic oxidative burden evoked by a single apheresis treatment.

Details

OriginalspracheEnglisch
Seiten (von - bis)34-38
Seitenumfang5
FachzeitschriftAtherosclerosis Supplements
Jahrgang10
Ausgabenummer5
PublikationsstatusVeröffentlicht - 29 Dez. 2009
Peer-Review-StatusJa

Externe IDs

PubMed 20129371

Schlagworte

Ziele für nachhaltige Entwicklung

Schlagwörter

  • chemiluminescence, LDL apheresis methods, leukocytes, reactive oxygen species, systemic oxidative stress markers, total antioxidant capacity