Advanced glycation end products in uremia
Publikation: Beitrag in Fachzeitschrift › Übersichtsartikel (Review) › Beigetragen › Begutachtung
Beitragende
- Technische Universität Dresden
- Tokai University
Abstract
The term "advanced glycation end products" (AGEs) stands for a heterogenous group of amino acid derivatives that are formed via glycation processes between peptide-bound lysine or arginine derivatives and carbonyl compounds, processes originally known from food systems as "Maillard reactions." AGEs accumulate in plasma and tissues with advancing age, diabetes, and particular renal failure. In vivo and in vitro studies indicate that AGEs represent an important class of uremic toxins. This review focuses on the chemistry behind the formation of AGEs, possible mechanisms underlying the accumulation of AGEs in uremia, clinical and therapeutic implications, and possible nutritional consequences. (C) 2003 by the National Kidney Foundation, Inc.
Details
Originalsprache | Englisch |
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Seiten (von - bis) | 321-331 |
Seitenumfang | 11 |
Fachzeitschrift | Advances in renal replacement therapy |
Jahrgang | 10 |
Ausgabenummer | 4 |
Publikationsstatus | Veröffentlicht - Okt. 2003 |
Peer-Review-Status | Ja |
Externe IDs
Scopus | 0348048493 |
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Schlagworte
Ziele für nachhaltige Entwicklung
Schlagwörter
- advanced glycation end products, uremia, GLUCOSE DEGRADATION PRODUCTS, PERITONEAL-DIALYSIS FLUID, REACTIVE CARBONYL-COMPOUNDS, INCREASED OXIDATIVE STRESS, ENDOTHELIAL GROWTH-FACTOR, MAILLARD REACTION-PRODUCT, IMIDAZOLIUM CROSS-LINKS, N-ALPHA-HIPPURYLLYSINE, STAGE RENAL-FAILURE, IN-VITRO