A comparison of pediatric inflammatory multisystem syndrome temporarily-associated with SARS-CoV-2 and Kawasaki disease

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Klinikum Obergöltzsch Rodewisch
  • Städtisches Klinikum Lüneburg
  • Städtisches Klinikum Karlsruhe gGmbH
  • Helios Klinikum Schwelm
  • German Academy for Pediatrics and Adolescent Medicine
  • Klinikum St. Georg Leipzig
  • Kinder- und Jugendkrankenhaus Auf der Bult
  • Darmstädter Kinderkliniken Prinzessin Margaret
  • Universitätsklinikum Ulm
  • Leopoldina Krankenhaus Schweinfurt
  • DONAU ISAR Klinikum Deggendorf-Dingolfing-Landau gKU
  • Klinikum Esslingen
  • Universität Duisburg-Essen
  • GPR Klinikum
  • Klinikum Wolfsburg
  • Carl-Thiem-Klinikum Cottbus
  • Klinikum Lippe
  • Kliniken der Stadt Köln gGmbH
  • Oberschwabenklinik Ravensburg
  • Evangelisches Klinikum Bethel (EvKB)
  • Universitätsklinikum Schleswig-Holstein Campus Lübeck
  • Technische Universität München
  • Ruhr-Universität Bochum
  • Klinikum Landkreis Freudenstadt gGmbH
  • Medizinische Universität Innsbruck
  • Klinikum Bremen-Mitte
  • Artemed Kliniken Freiburg (AKF) gGmbH
  • Diakonie Krankenhaus Bad Kreuznach
  • St. Marien- und St. Annastiftskrankenhaus Ludwigshafen
  • Helios Klinikum Duisburg
  • Helios Klinikum Pforzheim
  • Helios Klinikum Hildesheim
  • Universität Hamburg

Abstract

The connection between Pediatric Inflammatory Multisystem Syndrome (PIMS) and Kawasaki Disease (KD) is not yet fully understood. Using the same national registry, clinical features and outcome of children hospitalized in Germany, and Innsbruck (Austria) were compared. Reported to the registry were 395 PIMS and 69 KD hospitalized patients. Patient age in PIMS cases was higher than in KD cases (median 7 [IQR 4–11] vs. 3 [IQR 1–4] years). A majority of both PIMS and KD patients were male and without comorbidities. PIMS patients more frequently presented with organ dysfunction, with the gastrointestinal (80%), cardiovascular (74%), and respiratory (52%) systems being most commonly affected. By contrast, KD patients more often displayed dermatological (99% vs. 68%) and mucosal changes (94% vs. 64%), plus cervical lymph node swelling (51% vs. 34%). Intensive care admission (48% vs. 19%), pulmonary support (32% vs. 10%), and use of inotropes/vasodilators (28% vs. 3%) were higher among PIMS cases. No patients died. Upon patient discharge, potentially irreversible sequelae—mainly cardiovascular—were reported (7% PIMS vs. 12% KD). Despite differences in age distribution and disease severity, PIMS and KD cases shared many common clinical and prognostic characteristics. This supports the hypothesis that the two entities represent a syndrome continuum.

Details

OriginalspracheEnglisch
Aufsatznummer1173
Seiten (von - bis)1-14
Seitenumfang14
FachzeitschriftScientific reports
Jahrgang13
Ausgabenummer2023
PublikationsstatusVeröffentlicht - 1 Dez. 2023
Peer-Review-StatusJa

Externe IDs

PubMed 36670127

Schlagworte

Ziele für nachhaltige Entwicklung

ASJC Scopus Sachgebiete

Schlagwörter

  • Child, Humans, Male, Female, COVID-19/complications, SARS-CoV-2, Mucocutaneous Lymph Node Syndrome/complications, Systemic Inflammatory Response Syndrome/complications

Bibliotheksschlagworte